Results 181 to 190 of about 13,343,923 (331)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Clinical study on closed Kirschner wire prying reduction for Gartland Type IV supracondylar humeral fractures in children and analysis of typical cases. [PDF]

Front Surg
Wu Y, Wen J, Hui W, Wang J, Yang F, Qiu X, Peng Y, Yuan Z.   +7 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The prevalence of clinically significant proximal femoral growth disturbance following open versus closed reduction in dysplastic hips performed after 6 months: A systematic review and meta-analysis of 150 studies. [PDF]

J Child Orthop
Cheok T, Boppana A, Christiansen J, Beveridge A, Jordan W, Martin R, Van Hout Z, Rawat J.   +7 more
europepmc   +1 more source

UN approval of greenhouse gas emission reduction projects in developing countries: The political economy of the CDM Executive Board

, 2008
Florens Flues, Axel Michaelowa, Katharina Michaelowa   +2 more
openalex   +1 more source

Electrocatalytic CO2 reduction at low overpotentials using iron(III) tetra(meso-thienyl)porphyrins [PDF]

, 2019
Josh D. B. Koenig, Janina Willkomm, Roland Roesler, Warren E. Piers, Gregory C. Welch   +4 more
openalex   +1 more source

Cation-induced changes in the inner- and outer-sphere mechanisms of electrocatalytic CO2 reduction-related dataset

, 2023
Xueping Qin, Heine Anton Hansen, Karoliina Honkala, Marko Melander   +3 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Nutritional And Biochemical Effects OfGum Arabic On The Pathological Changes Reduction OfAlloxan Induced Diabetic Rats [PDF]

, 2018
EnsafM. Yassin
openalex   +1 more source

Reactivity of Multimetallic Thorium Nitrides Generated by Reduction of Thorium Azides

, 2022
Fang‐Che Hsueh, Luciano Barluzzi, Megan Keener, Thayalan Rajeshkumar, Laurent Maron, Rosario Scopelliti, Marinella Mazzanti   +6 more
openalex   +1 more source