Results 61 to 70 of about 4,351 (191)

Oncoplastic breast surgery – a pictorial classification system for surgeons and radiation oncologists (OPSURGE)

ANZ Journal of Surgery, Volume 94, Issue 12, Page 2140-2149, December 2024.
Changes to the tumour bed following oncoplastic surgery complicate the administration of adjuvant radiotherapy. A framework for tumour bed classification is proposed (OPSURGE) to aid communication between oncoplastic surgeons and radiation oncologists, particularly when using a boost dose to the primary tumour site. Abstract Introduction Changes to the
Matthew Binks, John Boyages, Hiroo Suami, Nicholas Ngui, Farid Meybodi, T. Michael Hughes, Senarath Edirimanne   +6 more
wiley   +1 more source

Prelude to malignancy: A gene expression signature in normal mammary gland from breast cancer patients suggests pre‐tumorous alterations and is associated with adverse outcomes

International Journal of Cancer, Volume 155, Issue 9, Page 1616-1628, 1 November 2024.
What's new? Patients who undergo breast‐conserving surgery for breast cancer have a significant risk of recurrence if the healthy tissue left behind harbors cancer‐predisposing alterations. Here, the authors use a custom‐made gene panel, to potentially identify the risk of recurrence by detecting such alterations.
Maria Andreou, Marcin Jąkalski, Katarzyna Duzowska, Natalia Filipowicz, Anna Kostecka, Hanna Davies, Monika Horbacz, Urszula Ławrynowicz, Katarzyna Chojnowska, Bożena Bruhn‐Olszewska, Jerzy Jankau, Ewa Śrutek, Manuela Las‐Jankowska, Dariusz Bała, Jacek Hoffman, Johan Hartman, Rafał Pęksa, Jarosław Skokowski, Michał Jankowski, Łukasz Szylberg, Mateusz Maniewski, Wojciech Zegarski, Magdalena Nowikiewicz, Tomasz Nowikiewicz, Jan P. Dumanski, Jakub Mieczkowski, Arkadiusz Piotrowski   +26 more
wiley   +1 more source

Comparing coverage of medically indicated reduction mammoplasty among Swiss health insurers: a retrospective study

Swiss Medical Weekly
BACKGROUND: Reduction mammoplasty is commonly used to treat macromastia, highlighting the need to address the physical and psychosocial issues associated with breast hypertrophy.
Marlon Petrus, Silke Graul, Rafael Loucas, Julius M. Mayer, Sebastian Leitsch, Thomas Holzbach   +5 more
doaj   +1 more source

Benign breast tumors may arise on different immunological backgrounds

Molecular Oncology, Volume 18, Issue 10, Page 2495-2509, October 2024.
Benign breast tumors lack invasive potential, offering insights into tumor biology. Our study, using pathway analysis, identified immune‐related pathways distinguishing benign from malignant tumors. Five pathways linked to cytokine and interferon signaling correlated with overall survival.
Lilly Anne Torland, Xiaoran Lai, Surendra Kumar, Margit H. Riis, Jürgen Geisler, Torben Lüders, Xavier Tekpli, Vessela Kristensen, Kristine Sahlberg, Andliena Tahiri   +9 more
wiley   +1 more source

Emergence of the natural history of Myhre syndrome: 47 patients evaluated in the Massachusetts General Hospital Myhre Syndrome Clinic (2016–2023)

American Journal of Medical Genetics Part A, Volume 194, Issue 10, October 2024.
Abstract Myhre syndrome is an increasingly diagnosed ultrarare condition caused by recurrent germline autosomal dominant de novo variants in SMAD4. Detailed multispecialty evaluations performed at the Massachusetts General Hospital (MGH) Myhre Syndrome Clinic (2016–2023) and by collaborating specialists have facilitated deep phenotyping, genotyping and
Angela E. Lin, Eleanor R. Scimone, Robyn P. Thom, Duraisamy Balaguru, T. Bernard Kinane, Peter P. Moschovis, Michael S. Cohen, Weizhen Tan, Cole D. Hague, Katelyn Dannheim, Lynne L. Levitsky, Evelyn Lilly, Daniel V. DiGiacomo, Kara M. Masse, Sarah M. Kadzielski, Claire A. Zar‐Kessler, Leo C. Ginns, Ann M. Neumeyer, Mary K. Colvin, Jack S. Elder, Christopher P. Learn, Hongmei Mou, Kathryn M. Weagle, Karen A. Buch, William E. Butler, Kenda Alhadid, Patricia L. Musolino, Sadia Sultana, Dhrubajyoti Bandyopadhyay, Otto Rapalino, Zachary S. Peacock, Elizabeth L. Chou, Gena Heidary, Aaron T. Dorfman, Shaine A. Morris, James D. Bergin, Jonathan H. Rayment, Lisa A. Schimmenti, Mark E. Lindsay, MGH Myhre Syndrome Study Group, Luisa Paredes Acosta, Jennifer A. Bassetti, Sarah Bowdin, Joy A. Bress, Joseph A. Camarda, Joanne S. Chiu, C. Eduardo Corrales, Gregory Costain, Mary Beth P. Dinulos, Rajiv Devanagondi, Emily S. Doherty, John Dykes, Ann‐Christine Duhaime, Robert F. English, Elizabeth Fieg, Nora D. B. Friedman, Carl P. Garabedian, Samantha Glowacki, Barbara R. Gottlieb, Mary Hope Griffin, Frances J. Hayes, Stephanie R. Hicks, Alicia M. Hinze, Brigette A. Jason, Joel Krier, Kristen Lindgren, Michael Lyons, Adnan Majid, Hannah C. Mannem, Marie McDonald, Vinod Misra, Amy Morgan, Barbara J. Nath, Michele Ploutz, Eloise J. Prijoles, Margaret B. Pulsifer, Alicia M. Quesnel, Farrah Rajabi, Mersedeh Rohanizadegan, Ana Maria Rosales, Holly Rothermel, Edith Schussler, Elizabeth A. Sellars, Joseph Shieh, Stephanie Sherrill, Heidi Taska‐Tench, Matthew Thompson, George E. Tiller, Stephanie E. Vallee, David Viskochil, Stephanie Ware, Rachel C. Whooten, Samuel Yang, Elaine H. Zackai, Dala Zakaria   +94 more
wiley   +1 more source

Single‐cell transcriptional atlas of human breast cancers and model systems

Clinical and Translational Medicine, Volume 14, Issue 10, October 2024.
Patient‐derived xenografts models more closely resemble patient samples in tumour heterogeneity and cell cycle characteristics when compared with cell lines. 3D organoid models exhibit differences in metabolic profiles compared to their in vivo counterparts. A valuable multimodel reference dataset that can be useful in elucidating model differences and
Julia E. Altman, Amy L. Olex, Emily K. Zboril, Carson J. Walker, David C. Boyd, Rachel K. Myrick, Nicole S. Hairr, Jennifer E. Koblinski, Madhavi Puchalapalli, Bin Hu, Mikhail G. Dozmorov, X. Steven Chen, Yunshun Chen, Charles M. Perou, Brian D. Lehmann, Jane E. Visvader, J. Chuck Harrell   +16 more
wiley   +1 more source

Reduction mammoplasty in a developing country: A 10-year review (2001-2010) at the national orthopaedic hospital, Enugu

Nigerian Journal of Surgery, 2015
Context: Large breast is a major problem because of associated symptomatology and aesthetic concerns. Reduction mammoplasty (RM) resolves the symptom and at the same time improves the aesthetic appearance of the breast, hence improving self-esteem and ...
Chimaobi Isiguzo, Sunday Iheuko Ogbonnaya, Anthonia O Uduezue   +2 more
doaj   +1 more source

Dehydroepiandrosterone‐α‐2‐Deoxyglucoside Exhibits Enhanced Anticancer Effects in MCF‐7 Breast Cancer Cells and Inhibits Glucose‐6‐Phosphate Dehydrogenase Activity

Chemical Biology &Drug Design, Volume 104, Issue 3, September 2024.
Dehydroepiandrosterone‐α‐2‐deoxyglucoside (DHEA‐α‐2‐DG) is a rare stereospecific conjugate of DHEA and 2‐DG with anticancer activity far superior to that of 2‐DG, approximately four times that of DHEA, and better than that of polydatin. It also inhibited G6PD activity in vitro, decreased the NADPH/NADP+ ratio in MCF‐7 cell activity assay, and inhibited
Hsu‐Feng Liu, Shen‐Chieh Chou, Sheng‐Cih Huang, Tzu‐Yu Huang, Po‐Yun Hsiao, Feng‐Pai Chou, Tung‐Kung Wu   +6 more
wiley   +1 more source

Mesenchymal Stromal Cells Increase the Natural Killer Resistance of Circulating Tumor Cells via Intercellular Signaling of cGAS‐STING‐IFNβ‐HLA

Advanced Science, Volume 11, Issue 21, June 5, 2024.
This study shows that circulating tumor cells, before dissemination from a primary tumor, are empowered to escape NK cell surveillance and form metastasis by cross‐talking with mesenchymal stromal cells in the tumor microenvironment via an intercellular cGAS‐cGAMP‐STING‐IFNβ‐HLA‐I signaling loop. The new mechanism may provide novel therapeutic targets.
Ye Yi, Guihui Qin, Hongmei Yang, Hao Jia, Qibing Zeng, Dejin Zheng, Sen Ye, Zhiming Zhang, Tzu‐Ming Liu, Kathy Qian Luo, Chu‐Xia Deng, Ren‐He Xu   +11 more
wiley   +1 more source

Rash with DERMABOND PRINEO Skin Closure System Use in Bilateral Reduction Mammoplasty: A Case Series

Case Reports in Medicine, 2015
Background. Bilateral reduction mammoplasty is a common plastic surgery procedure that can be complicated by unfavorable scar formation along incision sites.
R. W. Knackstedt, J. A. Dixon, P. J. O’Neill, F. A. Herrera   +3 more
doaj   +1 more source