Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Enhanced dust reduction method for solar panels application. [PDF]
Sci RepHooshyar P, Moosavi A, Borujerdi AN.
europepmc +1 more source
A Noise Reduction Method for Four-Mass Vibration MEMS Gyroscope Based on ILMD and PTTFPF. [PDF]
Micromachines (Basel), 2022 Li Z, Gu Y, Yang J, Cao H, Wang G.
europepmc +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Minimally invasive treatment of posterolateral tibial plateau fractures with bamboo raft reduction method combined with jail screws: A case report. [PDF]
Int J Surg Case RepLi K, Li Y, Wang Y, Chen Y.
europepmc +1 more source
A Dynamic RCS and Noise Prediction and Reduction Method of Coaxial Tilt-Rotor Aircraft Based on Phase Modulation. [PDF]
Sensors (Basel), 2022 Wang Z, Huang J, Yi M, Lu S.
europepmc +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
The analysis of the progressive local failure process of the Longquan Reservoir dam based on the global-local dynamic strength reduction method. [PDF]
Sci RepQu X, Diao F, Li C, Xu X, Wang Z, Hao S.
europepmc +1 more source
Slope monitoring optimization considering three-dimensional deformation and failure characteristics using the strength reduction method: A case study. [PDF]
Sci Rep, 2023 Wang J +7 more
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source