Results 261 to 270 of about 2,926,234 (312)

Vibration Signal Noise-Reduction Method of Slewing Bearings Based on the Hybrid Reinforcement Chameleon Swarm Algorithm, Variate Mode Decomposition, and Wavelet Threshold (HRCSA-VMD-WT) Integrated Model. [PDF]

Sensors (Basel)
Li Z, Yao X, Zhang C, Qian Y, Zhang Y.
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Fast treatment of anterior shoulder dislocations with two sedation-free methods: The Davos self-reduction method and Arlt method. [PDF]

Shoulder Elbow
Widmer LW, Lerch TD, Genthner A, Pozzi L, Geiger J, Frei HC.   +5 more
europepmc   +1 more source

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Generalized Petri Net Reduction Method

IEEE Transactions on Systems, Man, and Cybernetics, 1987
A reduction method of generalized Petri nets is proposed. This method is a generalization of the reduction method which was previously given by the first two authors [ibid. 15, 272-280 (1985; Zbl 0564.68047)]. The proposed method is defined not on the basis of the dynamic behavior but of the structure of the net, and thus the test of reducible subnet ...
LEEKWANG, H Lee, Kwang-Hyung, FAVREL, J FAVREL, J, BAPTISTE, P BAPTISTE, P   +2 more
openaire   +5 more sources

A Method of Model Reduction

Journal of Dynamic Systems, Measurement, and Control, 1986
In this brief note, the effects of model reduction on the stability boundaries of control systems with parameter variations, and the limit-cycle characteristics of nonlinear control systems are investigated. In order to reduce these effects, a method of model reduction is used which can approximate the original transfer function at S=0, S=∞, and also ...
Lin, Jium-Ming, Han, Kuang-Wei
openaire   +2 more sources

Matrix reduction—an efficient method

Communications of the ACM, 1975
The paper describes an efficient method for reduction of the binary matrices which arise in some school time-tabling problems. It is a development of that described by John Lions. It has been generalized and adapted to fit into the complete timetabling process; to use a more compact data representation and more efficient processing techniques; to take ...
H. C. Johnston, C. A. R. Hoare
openaire   +1 more source