Results 81 to 90 of about 6,804,387 (286)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Reduced Complexity SLM Method for PAPR Reduction

Journal of Engineering, 2019
In this paper, the computational complexity will be reduced using a revised version of the selected mapping (SLM) algorithm. Where a partial SLM is achieved to reduce the mathematical operations around 50%. Although the peak to average power ratio (PAPR)
Zahraa Ali Jawad
doaj   +1 more source

Variance reduction methods [PDF]

Proceedings of the 18th conference on Winter simulation - WSC '86, 1986
A computer simulation model is unusual in that the random error is under the total control of the experimenter. Variance reduction methods aim to take advantage of this to improve experimental accuracy. The fundamental ideas behind the most important of these methods will be described and illustrated with simple examples.
openaire   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Method and apparatus for background signal reduction in opto-acoustic absorption measurement [PDF]

, 1976
The sensitivity of an opto-acoustic absorption detector is increased to make it possible to measure trace amounts of constituent gases. A second beam radiation path is created through the sample cell identical to a first path except as to length ...
Rosengren, L. G.
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Infinitely many solutions for Hamiltonian system with critical growth

Advances in Nonlinear Analysis
In this article, we consider the following elliptic system of Hamiltonian-type on a bounded domain:−Δu=K1(∣y∣)∣v∣p−1v,inB1(0),−Δv=K2(∣y∣)∣u∣q−1u,inB1(0),u=v=0on∂B1(0),\left\{\begin{array}{ll}-\Delta u={K}_{1}\left(| y| ){| v| }^{p-1}v,\hspace{1.0em ...
Guo Yuxia, Hu Yichen
doaj   +1 more source

Reduction Method for Mobile Laser Scanning Data

ISPRS International Journal of Geo-Information, 2018
Mobile Laser Scanning (MLS) technology acquires a huge volume of data in a very short time. In many cases, it is reasonable to reduce the size of the dataset with eliminating points in such a way that the datasets, after reduction, meet specific ...
Wioleta Błaszczak-Bąk, Zoltan Koppanyi, Charles Toth   +2 more
doaj   +1 more source