Results 61 to 70 of about 293,359 (293)

Cyberspace Endogenous Safety and Security

Engineering, 2022
Uncertain security threats caused by vulnerabilities and backdoors are the most serious and difficult problem in cyberspace. This paper analyzes the philosophical and technical causes of the existence of so-called “dark functions” such as system ...
Jiangxing Wu
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Research on the method of mass estimation for heavy vehicles

Journal of Hebei University of Science and Technology, 2018
To solve the vehicle mass estimation problems, two vehicle mass estimation methods based on both commonly used dynamics method and kinematic method are analyzed by simulation and experimental study.
Tianle JIA, Hongliang WANG, Pai PENG, Dong XUE   +3 more
doaj   +1 more source

Dynamic Multi-Objective Optimization Inverse Prediction of Excavation-Induced Tunnel Displacement

Shanghai Jiaotong Daxue xuebao, 2022
Control of the disturbed displacement of adjacent tunnel during excavation is a significant issue for design and construction. Based on the multi-objective optimization method, the multi-type monitoring data in the excavation of the excavation are ...
HE Wei, SUN Honglei, TAO Yuanqin, CAI Yuanqiang
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The Impact of Redundancy and Teamwork on Resilience Engineering Factors by Fuzzy Mathematical Programming and Analysis of Variance in a Large Petrochemical Plant

Safety and Health at Work, 2016
Background: Resilience engineering (RE) is a new paradigm that can control incidents and reduce their consequences. Integrated RE includes four new factors—self-organization, teamwork, redundancy, and fault-tolerance—in addition to conventional RE ...
Ali Azadeh, Vahid Salehi, Mahsa Mirzayi
doaj   +1 more source

Protein engineering in the big data era: harnessing near-redundant structural data [PDF]

, 2020
Abstract Motivation: Predicting the effect of mutations on protein-protein interactions is important for relating structure to function, as well as for in silico affinity maturation. The effect of mutations on protein-protein binding energy (ΔΔG) can be predicted by a variety of atomic simulation methods involving full or limited flexibility ...
Samuel Coulbourn Flores, Athanasios Alexiou, Anastasios Glaros   +2 more
openaire   +2 more sources

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Innovating Aircraft Repair Processes: The Role of Digitalization in Sustainability

Advanced Engineering Materials, EarlyView.
This research explores how digitalization—by storing detailed non‐destructive testing data in structured DICONDE databases and creating a standard data model of the component—innovates aviation maintenance and repair processes. Coupled with a developed state‐based simulation model, it enables data‐driven, sustainable repair strategies that reduce waste,
Johanna Aigner, Geo Jacob, Florian Raddatz, Gerko Wende   +3 more
wiley   +1 more source

A retrieval augmented generation based optimization approach for medical knowledge understanding and reasoning in large language models

Array
Based on the existing Retrieval Augmented Generation (RAG) technology, this study proposes innovative solution to better address the hallucination issues of current large language models.
Yingshuai Wang, Yanli Wan, Xingyun Lei, Qingkun Chen, Hongpu Hu   +4 more
doaj   +1 more source