Results 111 to 120 of about 865,993 (309)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Research on control strategies for joint point tracking in coordinated motion of dual-redundant robots

Jixie chuandong
ObjectiveWith the complexity of operational tasks, the dual-redundant robots have more operational flexibility and adaptability than the six-DOF robot arms. Aiming at the security problems in the information interaction and coordinated motion between the
GAO Lin, ZHANG Zhiyuan, WANG Shaofeng, SHI Yanqing, YU Pengwei, LIANG Chaohui   +5 more
doaj  

Requirements Analysis of a Quad-Redundant Flight Control System

, 2015
In this paper we detail our effort to formalize and prove requirements for the Quad-redundant Flight Control System (QFCS) within NASA's Transport Class Model (TCM).
Backes, John, Cofer, Darren, Miller, Steven, Whalen, Mike   +3 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Research on failure free systems Quarterly report no. 8, Mar. 23 - Jun. 23, 1966 [PDF]

Failure free electronic systems - computer simulation program documentation and redundant system test point allocation and reliability ...

core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Lattice dynamical wavelet neural networks implemented using particle swarm optimisation for spatio-temporal system identification [PDF]

, 2007
Starting from the basic concept of coupled map lattices, a new family of adaptive wavelet neural networks, called lattice dynamical wavelet neural networks (LDWNN), is introduced for spatiotemporal system identification, by combining an efficient wavelet
Billings, S.A., Guo, L.Z., Wei, H.L., Zhao, Y.F.   +3 more
core  

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Development of undulator motion control system with redundant protections

AIP Advances
The undulator is a key luminous component of the Shanghai high repetition rate x-ray free electron laser and extreme light facility, and the motion control system is an important part of the undulator.
Yangyang Lei, Qibing Yuan, Wei Zhang, Shudong Zhou, Shengwang Xiang, Haixiao Deng, Bo Liu   +6 more
doaj   +1 more source