Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Modeling Loss Aversion and Reference Dependence Effects on Brand Choice
Bruce G. S. Hardie +2 more
openalex +2 more sources
Off-Axis Illumination and Epicollection Confocal Brillouin Scattering Microspectroscopy. [PDF]
Yui H +4 more
europepmc +1 more source
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Clinical evaluation of two new unshielded and shielded silicon diode detectors in external photon beam radiation therapy: SunSILICON and SunSILICON P. [PDF]
Anders TJ +13 more
europepmc +1 more source
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
First evaluation of a heteroepitaxial diamond ionization chamber operating at low voltage for diagnostic X-ray dosimetry. [PDF]
Shinsho K +12 more
europepmc +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Essays on reference dependence in macroeconomics : theory and evidence
Livio. Stracca
openalex +1 more source
Do AI-based contouring algorithms influence physicians in the online adaptive radiotherapy of patients with bladder cancer? [PDF]
Guberina N +15 more
europepmc +1 more source

