Results 61 to 70 of about 2,353,500 (291)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Perspectivism and Special Relativity

Teorie vědy, 2021
The special theory of relativity holds significant interest for scientific perspectivists. In this paper, I distinguish between two related meanings of “perspectival,” and argue that reference frames are perspectives, provided that perspectival means ...
Mahdi Khalili
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

An Accurate Multi-Row Panorama Generation Using Multi-Point Joint Stitching

IEEE Access, 2018
Most of the existing panorama generation tools require the input images to be captured along one direction, and yield a narrow strip panorama. To generate a large viewing field panorama, this paper proposes a multi-row panorama generation (MRPG) method ...
Jin Zheng, Zhi Zhang, Qiuhao Tao, Kai Shen, Yue Wang   +4 more
doaj   +1 more source

Quantifying the resource of sharing a reference frame

, 2005
We define a new quantity called refbit, which allows one to quantify the resource of sharing a reference frame in quantum communication protocols. By considering both asymptotic and nonasymptotic protocols we find relations between refbits and other ...
S. J. van Enk, S. J. van Enk
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

3D kinematics using dual quaternions: theory and applications in neuroscience

Frontiers in Behavioral Neuroscience, 2013
In behavioral neuroscience, many experiments are developed in 1 or 2 spatialdimensions, but when scientists tackle problems in 3-dimensions (3D), theyoften face problems or new challenges. Results obtained for lower dimensionsare not always extendable in
Guillaume eLeclercq, Guillaume eLeclercq, Philippe eLefèvre, Philippe eLefèvre, Gunnar eBlohm, Gunnar eBlohm   +5 more
doaj   +1 more source

On the Observables Describing a Quantum Reference Frame

, 2000
A reference frame F is described by the element g of the Poincare' group P which connects F with a given fixed frame F_0. If F is a quantum frame, defined by a physical object following the laws of quantum physics, the parameters of g have to be ...
Aharonov Y., Castrigiano D. P. L., Cattaneo U., S. Mazzucchi, Toller M., Toller M., Werner R.   +6 more
core   +1 more source