Results 91 to 100 of about 6,060,916 (264)

Clinical Aspects of Thyrotropin Circadian Variability

Клиническая и экспериментальная тиреоидология, 2009
We retrospectively analyzed the results of measurements of serum TSH concentrations perfomed in 14760 outpatients since October 2008 till October 2009 (n = 14760) in Federal Endocrinological Research Center. Data have been parted on two groups.

doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Convex Interval Games [PDF]

In this paper, convex interval games are introduced and some characterizations are given. Some economic situations leading to convex interval games are discussed.
Brânzei, R., Tijs, S.H., Alparslan-Gok, S.Z.   +2 more
core  

Norm and reference interval in biochemistry – similarities and differences [PDF]

, 2021
The article is devoted to the definition of the essence of the concepts "norm" and "reference interval ", their similarities and differences in biochemistrical diagnostics.Статья посвящена определению сущности понятий «норма» и «референсное значение», их
Мещанинов, В. Н., Meshchaninov, V. N., Garipov, R. R., Гарипов, Р. Р.   +3 more
core  

Blood Vitamin Concentrations in Pond Sliders (Trachemys scripta) Under Human Care in Central Europe and Possible Seasonal and Sex-Specific Influences

Animals
Vitamin A deficiency is common in pond sliders, and vitamin E and B1 deficiencies have also been described in carnivorous aquatic species such as crocodiles, but otherwise little is known about vitamin concentrations in the blood of reptiles, and ...
Christoph Leineweber, Gregor Geisler, Sabine Öfner, Rachel E. Marschang   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Cooperation under Interval Uncertainty [PDF]

Classification: JEL code C71Cooperative game theory;Interval uncertainty;Core;Value ...
Miquel, S., Tijs, S.H., Alparslan-Gok, S.Z.   +2 more
core  

The difference between reference interval and reference range

Journal of Laboratory Medicine, 2020
Haeckel Rainer, Wosniok Werner, Streichert Thomas,   +3 more
doaj   +1 more source