Results 91 to 100 of about 2,470,673 (322)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Towards a Reference Framework for Software Product Management

14th IEEE International Requirements Engineering Conference (RE'06), 2006
In the last decade, software product management has received much practical attention, though research in this area is still scattered. In this paper, we present a reference framework for software product management, in which the key process areas, namely portfolio management, product roadmapping, release planning and requirements management, are ...
Weerd, I. van de, Brinkkemper, S., Nieuwenhuis, R., Versendaal, J.M., Bijlsma, L.   +4 more
openaire   +3 more sources

Pengaturan Lampu Lalu Lintas Berbasis Mikrokontroler Atmega8535 [PDF]

, 2012
It has built a simulator traffic lights to set the length of time the light is green, yellow, and red on a two-way street. Setting the length of time the lighting is made on the C language program listings using the software (software) proteus to solve ...
Alamsyah, A. (Alamsyah)
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Proposal of a Reference Model in BPMN Notation for an MRP System [PDF]

, 2018
Companies are progressively investing in practices aimed at improving the quality of management, with the main purpose of enabling them to operate competitively in the present market.
Entringer, T. C. (Tulio), Ferreira, A. D. (Ailton), Lewandowski, O. (Oscar), Nascimento, D. C. (Denise), Oliveira, L. J. (Luciano), Siqueira, P. M. (Paulo)   +5 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The 727 approach energy management system avionics specification (preliminary) [PDF]

Hardware and software requirements for an Approach Energy Management System (AEMS) consisting of an airborne digital computer and cockpit displays are presented. The displays provide the pilot with a visual indication of when to manually operate the gear,
Jackson, D. O., Lambregts, A. A.
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Determining Information Security Threats for an IoT-Based Energy Internet by Adopting Software Engineering and Risk Management Approaches

Inventions, 2019
This paper introduces an information security threat modeling (ISTM) scheme, which leverages the strengths of software engineering and risk management approaches, called I-SERM.
Yu-Tso Chen, Chuang-Chiao Huang
doaj   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source