Results 61 to 70 of about 2,470,673 (322)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Natural and Social Sciences Project Learning E-Module to Improve Science Process Skills in Aspects of Substances and Their Changes in Vocational Schools

Journal of Innovation in Educational and Cultural Research, 2023
Electronic modules are one solution to help students master and apply Science Process Skills in terms of creative economic and social aspects of substances and their changes.
Heni Nuraeni, Leny Helyawati, Indarini Dwi Pursitasari   +2 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Reference Management Tools - Same, Same but Different

Nordic Journal of Information Literacy in Higher Education, 2019
Reference management is an essential part of academic practice, for staff and students alike, and software to support reference management has grown into a standard, almost universal, service across Higher Education institutions around the world.  The
Mette Bechman, Jeanette Ekstrøm, Kirstin Remvig   +2 more
doaj   +1 more source

Bibliography Management with Reference Management Software: A Case Study

, 2022
Reference management was not always as easy as it is currently due to the innovative software that began receiving popularity in 1980s. In 1980s, only two or three reference management software’s (RMSs) were available, but now >28 RMSs are accessible to research scholars, students, faculty members, and librarians.
openaire   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

PDF Management Software Based on Reference Metadata:iPapers

Igaku Toshokan, 2007
The handling of referenced articles is one of the most typical tasks of researchers. Nonetheless, the work is important to the progress of research even though it involves monotonous, laborious, boring, and routine tasks. Recently, most publishers provide portable document format (PDF, Adobe Systems) versions of articles and researchers have to manage ...
Toshihiro AOYAMA, Hiroyuki SAKAI, Shiro USUI   +2 more
openaire   +2 more sources

Version 0.1 of the BigDAWG Polystore System

, 2017
A polystore system is a database management system (DBMS) composed of integrated heterogeneous database engines and multiple programming languages. By matching data to the storage engine best suited to its needs, complex analytics run faster and flexible
Dziedzic, Adam, Elmore, Aaron, Gadepally, Vijay, Kepner, Jeremy, Madden, Samuel, Mattson, Tim, OBrien, Kyle, Rogers, Jennie, She, Zuohao, Stonebraker, Michael   +9 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source