Results 231 to 240 of about 11,409,850 (299)

SI-traceable characterisation of the first reference material for nanoparticle number concentration in suspension to support regulatory compliance. [PDF]

Anal Bioanal Chem
Bartczak D, Nuñez SC, Kubicka A, Ojeda D, Cachero AS, Cowen S, Ellison S, Holcombe G, Goenaga-Infante H.   +8 more
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Establishment of Reference Measurement Procedure for <i>TP53</i> R175H/R248W Detection and a Novel Preparation Method for ctDNA Reference Material. [PDF]

Genes (Basel)
Tang Y, Niu C, Zhang J, Dong L, Yang J.
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Antiphospholipid IgG Certified Reference Material ERM^®-DA477/IFCC: a tool for aPL harmonization? [PDF]

Clin Chem Lab Med
Grossi C, Deprez L, Bodio C, Borghi MO, Kumar S, Pozzi N, Macor P, Piantoni S, Tincani A, Radin M, Sciascia S, Martos G, Monogioudi E, Zegers I, Sheldon J, Willis R, Meroni PL.   +16 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Development of a new reference material for accurate measurements of lithium in Li-clays. [PDF]

Sci Rep
Quiroz Garduño LD, Mora García TD, Domínguez AS, Valle Moya E, Martínez Ríos FJ, Del Rocío Arvizu Torres M, Amezcua Vergara M, Hernández Leos R, Hernández Rodríguez C, Pérez García MR, de Jesús Pérez Bueno J.   +10 more
europepmc   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Development of Certified Reference Material Solutions for Phytochemicals in Ginger and Kava. [PDF]

J AOAC Int
Aijaz SM, Ruan Z, Leija C, Lytwak LA, Waddell S, Kuszak AJ, Wise SA, Sreenivasan U.   +7 more
europepmc   +1 more source