Results 81 to 90 of about 5,447,975 (305)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Teaching machine translation and translation technology: a contrastive study [PDF]

open access: yes, 2001
The Machine Translation course at Dublin City University is taught to undergraduate students in Applied Computational Linguistics, while Computer-Assisted Translation is taught on two translator-training programmes, one undergraduate and one ...
Kenny, Dorothy, Way, Andy
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

REFERENCE MATERIALS OF JSC "ENFMPP" - THE PAST, THE PRESENT, THE FUTURE

open access: yesСтандартные образцы, 2017
The history of "ENFMPP" has almost 100 years. The first sample, certified as a reference material, was issued in 1965. Since, over 1200 reference materials (as RM sets or single RM) of fine precious metals (PM) and PM and non-ferrous metal alloys were ...
E. A. Anchutina   +2 more
doaj  

Modeling material failure with a vectorized routine [PDF]

open access: yes, 1984
The computational aspects of modelling material failure in structural wood members are presented with particular reference to vector processing aspects.
Cramer, S. M., Goodman, J. R.
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Operational approach to the Uhlmann holonomy

open access: yes, 2007
We suggest a physical interpretation of the Uhlmann amplitude of a density operator. Given this interpretation we propose an operational approach to obtain the Uhlmann condition for parallelity.
A. Uhlmann   +8 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Development of a certified reference material for specific surface area of quartz sand

open access: yesСтандартные образцы, 2017
The paper presents results of conducting research on the development of a certified reference material (CRM) for specific surface area of quartz sand, which is practically non-porous and therefore has low specific surface area value ~ 0.8 m2/g.
Egor P Sobina
doaj   +1 more source

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