Results 201 to 210 of about 254,077 (262)

Associations Between Caregiver Smartphone Use in a Child's Presence and Motor Skills and Executive Function in Preschoolers: SUNRISE International Study. [PDF]

Child Care Health Dev
Toledo-Vargas M, Chong KH, Engberg E, Jáuregui A, Martins C, Byambaa A, López-Gil JF, Abdeta C, Mwase-Vuma T, El Hamdouchi A, Lubree H, Aoko OA, Chelly MS, Chia MYH, Ghofranipour F, Gonzalez-Santamaria J, Jarani J, Katewongsa P, Kontsevaya A, Singh P, Subedi N, Teo WP, Tiongco MM, Trampa K, Turab A, Užičanin E, Veldman SLC, Okely AD.   +27 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Benchmarking Large Language Models Against Psychiatry Residents Using Traditional Institutional Assessments. [PDF]

Indian J Psychol Med
Sethi MIS, Suhas S, Harbishettar V, Manjunatha N, Kumar CN, Bharadwaj R, Chakraborty T, Math SB.   +7 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Primary care experiences at the intersection of sexual minority status and long-term mental health conditions in England: a cross-sectional analysis using the English General Practice Patient Survey. [PDF]

EClinicalMedicine
Gomes-Mendes A, McManus S, van der Ven E, Dima D, Fett AK.   +4 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

The unexpected impact of the second year of Explo'Santé, a school-based health education programme on life skills development among 5th grade pupils in France: an interventional cohort study. [PDF]

BMC Public Health
Salque C, Darlington-Bernard A, Carrouel F, Darlington E.   +3 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Neuropsychological Correlates of Linguistic Skills in At-Risk and Typically Developing Readers Across Educational Stages. [PDF]

Brain Sci
Méndez-Freije I, Areces D, Rodríguez C.   +2 more
europepmc   +1 more source