Results 141 to 150 of about 6,610,133 (296)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

open access: yesFEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés   +2 more
wiley   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

open access: yesFEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Forest K. Harris

open access: yes, 1988
FOREST K. HARRIS NBS: 1925 ‑ 1971 Birth: August 26, 1902, Gibson County, Indiana Death: November 3, 1991, McLean, Virginia Education: Oklahoma University degrees in physics: BA, 1921; MS, 1923 Johns Hopkins University, PhD (Physics), 1932 Principal ...
National Institute of Standards and Technology
core  

What can functional transcranial Doppler ultrasonography reveal about the cerebral lateralization of writing

open access: yesFEBS Letters, EarlyView.
Which brain hemisphere controls writing? This review synthesizes all five functional transcranial Doppler studies of writing (handwriting and typing) published to date in adults and children. Right‐handers show left‐hemispheric dominance for the linguistic component of writing (written word generation), whereas findings for left‐handers remain ...
Marietta Papadatou‐Pastou
wiley   +1 more source

Reference Notes (January 2012)

open access: yes, 2012
Table of Contents includes: A Fond Farewell to Bill DeJohn; Martin Luther King Jr. Papers Online; AskMN Welcomes Two Libraries in December; Recommendation Engines for Education; Minitex ROI Offers ELM Class to OLLI; ELM Spotlight; ELM Personalized Video;
Minitex Reference Outreach & Instruction
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Clinically Adjudicated Reference Standards for Evaluation of Infectious Diseases Diagnostics. [PDF]

open access: yesClin Infect Dis, 2023
Patel R   +5 more
europepmc   +1 more source

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