Results 261 to 270 of about 2,899,179 (354)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Dobutamine stress echocardiography after positive CCTA: diagnostic performance using fractional flow reserve and instantaneous wave-free ratio as reference standards. [PDF]

Open Heart
Tjellaug Bråten A, Holte E, Wiseth R, Aakhus S.   +3 more
europepmc   +1 more source

{HiDyn} Deliverable D1 - Report describing the design, development and technical specification of a type of high-contrast-luminance reference standard (covering at least 6 orders of magnitude), including the determination of luminance with an expanded uncertainty no larger than 1 % for the brightest source and no larger than 2 % for the dimmest one

P. Kliment, Petr Linduška, Constantinos A. Bouroussis, Sumita Pommerol, Alejandro Ferrero, Johannes Ledig   +5 more
openalex   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Quantum Mechanical Quantitative Nuclear Magnetic Resonance Enables Digital Reference Standards at All Magnetic Fields and Enhances qNMR Sustainability. [PDF]

Anal Chem
Nishizaki Y, Sugimoto N, Miura T, Asakura K, Suematsu T, Korhonen SP, Lehtivarjo J, Niemitz M, Pauli GF.   +8 more
europepmc   +1 more source

EVALUATION OF THE DIAGNOSTIC PERFORMANCE OF THE HEMOSPARK+ HEMOGLOBIN METER: A COMPARATIVE ANALYSIS AGAINST THE MINDRAY BC760 FULLY AUTOMATED HEMATOLOGY ANALYZER REFERENCE STANDARD

M. Bindu*1, N Akshitha2, Praveena3
openalex   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Reassessing and Extending the European Standards of Care for Newborn Health: How to Keep Reference Standards in Line with Current Evidence. [PDF]

Children (Basel)
Geiger I, Kostenzer J, Matthäus V, On Behalf Of The Escnh Chair Committee, Mader S, Zimmermann LJI.   +5 more
europepmc   +1 more source

Measuring the activity of BioBrick promoters using an in vivo reference standard

, 2008
Dileep D. Monie, Aaron L. Glieberman, Kim de Mora, Michael J. Czar, John Cumbers, Caroline M. Ajo‐Franklin, Joseph H. Davis, Adam J. Rubin, Jason Kelly, Drew Endy   +9 more
openalex   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source