Results 181 to 190 of about 2,834,850 (218)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

DFGLM-TCM: an integrated knowledge-and experience-driven large language model system for Traditional Chinese Medicine practice. [PDF]

Chin Med
Zhong R, Liu D, Dai Y, Li Z, Song Z, Li Z, Zhang L, Chen S, Su Y, Sun Y, Zhang W, Jia P, Jiang M, Gao L, Hu K.   +14 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Can risk scoring systems (R.E.N.A.L, PADUA and (MC)2 scoring systems) and related risk factors predict complications of renal ablation? a meta-analysis. [PDF]

Front Oncol
Zeng Z, Ji P, He Y, Zhou Y, Li T, Zou L, Zhou T, Zhao H, Hu X, Chen W, Chen W.   +10 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Validation of artificial intelligence-assisted CBCT analysis for predicting inferior alveolar nerve proximity to impacted mandibular third molars: a diagnostic accuracy study. [PDF]

BMC Oral Health
Hu H, Wu J, Pu H, Liang J, Niu Y, Li J, Chen B, Ding Y.   +7 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Three-Dimensional Surface Topography for Entropy-Based Comparison of Sagittal Postural Classifications in Children. [PDF]

Sensors (Basel)
Wilczyński J, Gawlik M, Bieniek K, Szumilas P, Habik-Tatarowska N, Markowski K, Świetlak W, Michalska A.   +7 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Potential and pitfalls of personal reference intervals in general practice: A focus group and case vignette study among Dutch general practitioners. [PDF]

Eur J Gen Pract
Krimpenfort RA, Drewes YM, den Elzen WPJ, Poortvliet RKE, de Boer BA, de Jong AM.   +5 more
europepmc   +1 more source