Results 111 to 120 of about 1,637,542 (298)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

AbstractMaster® [PDF]

Master is a powerful search/data management software specifically designed to help quickly locate relevant medical articles indexed by the National Library of Medicine* (NLM), to help keep track searches, what one has read, catalog references and full ...
D. Marr
core  

Managing Research Data in Big Science [PDF]

, 2012
The project which led to this report was funded by JISC in 2010--2011 as part of its 'Managing Research Data' programme, to examine the way in which Big Science data is managed, and produce any recommendations which may be appropriate.
Carozzi, Tobia, Gray, Norman, Woan, Graham   +2 more
core   +1 more source

Prioritized Garbage Collection: Explicit GC Support for Software Caches

, 2016
Programmers routinely trade space for time to increase performance, often in the form of caching or memoization. In managed languages like Java or JavaScript, however, this space-time tradeoff is complex.
Berger, Emery D., Guyer, Samuel Z., Nunez, Diogenes   +2 more
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Rainfall Intensity–Duration–Frequency Curves Dataset for Brazil

Data
This is a database containing rainfall intensity–duration–frequency equations (IDF equations) for 6550 pluviographic and pluviometric stations in Brazil.
Ivana Patente Torres, Roberto Avelino Cecílio, Laura Thebit de Almeida, Marcel Carvalho Abreu, Demetrius David da Silva, Sidney Sara Zanetti, Alexandre Cândido Xavier   +6 more
doaj   +1 more source

Scoping study of the feasibility of developing a software tool to assist designers of pedestrian crossing places [PDF]

, 2009
This report is the outcome of a scoping study of how guidance can be provided for practising highway engineers in designing informal pedestrian crossing facilities.
Allsop, R.E., Heydecker, B.G., Morgan, S., Robertson, S.A.   +3 more
core  

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source

Comprehensive Review and Future Research Directions on ICT Standardisation

Information
Standardisation has become imperative to retaining order and development in modern society. The simplest actions, such as train timings and the width of the railroad, would be very difficult to achieve without Standardisation. Standardisation also solves
Mohammed Najah Mahdi, Ray Walshe, Sharon Farrell, Harshvardhan J. Pandit   +3 more
doaj   +1 more source