Results 61 to 70 of about 1,637,542 (298)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
The implementation of telehealth in disease management at patient-centered medical home [PDF]
, 2018 Purpose: Telehealth (TH) and video conferencing in the patient-centered medical home (PCMH) can bridge geographical gaps between patients and providers, by eliminating the inconveniences of leaving the house and traveling to appointments.
Nurkanovic, Mirsada
core +1 more source
HBIM for Conservation: A New Proposal for Information Modeling
Remote Sensing, 2019 Thanks to its capability of archiving and organizing all the information about a building, HBIM (Historical Building Information Modeling) is considered a promising resource for planned conservation of historical assets.
Nazarena Bruno, Riccardo Roncella
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
DAS: a data management system for instrument tests and operations
, 2014 The Data Access System (DAS) is a metadata and data management software system, providing a reusable solution for the storage of data acquired both from telescopes and auxiliary data sources during the instrument development phases and operations.
Bulgarelli, Andrea +15 more
core
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Ontology-based domain modelling for consistent content change management [PDF]
, 2010 Ontology-based modelling of multi-formatted software application content is a challenging area in content management. When the number of software content unit is huge and in continuous process of change, content change management is important.
Abgaz, Yalemisew +2 more
core +1 more source
Designing Open Educational Resources through Knowledge Maps to enhance Meaningful learning [PDF]
, 2008 This paper demonstrates some pedagogical strategies for developing Open Educational Resources (OERs) using the knowledge mapping tool Compendium. It also describes applications of Knowledge Maps to facilitate meaningful learning by focusing on specific ...
Connolly, Teresa, Okada, Alexandra
core +2 more sources
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Citation and Content Analysis of Journal of Health Management and Informatics in 2014-2016
Journal of Health Management & Informatics, 2018 Background: The aim of citation and content analysis is to improve the quality of scientific productions, identify the authors’ trends, etc., and finally provide solutions to improve the present status. Therefore, the aim of this study was to determine
Reza Mohammadi +5 more
doaj