Results 201 to 210 of about 2,877,856 (360)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Referral to and Engagement with Pulmonary Rehabilitation: A Review and Strategic Behavioural Analysis of Factors Influencing Behaviour and Intervention Opportunities. [PDF]

Int J Chron Obstruct Pulmon Dis
Moore AP, Reardon I, Ramkissoon O, Early F, Payerne E, Ashford PA, Holmes S, Kelly MP, Singh SJ, Habib GMM, Fuld J, Lorencatto F, UPTURN Team.   +12 more
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

An evaluation of the Northumberland exercise on referral scheme: Preliminary results on predicting dropout for overweight and obese referrals

, 2012
Linda Allin - ORCID: 0000-0002-8101-6631 https://orcid.org/0000-0002-8101-6631Item is not available in this repository ...
Allin, Linda, Ellis, Jason, Hanson, Coral, Reynolds, Caroline   +3 more
core  

Reimagining the family physician-specialist relationship amid the primary care crisis: Harnessing power for better collaboration. [PDF]

Can Fam Physician
Wong R, Keely E, Pariser P.
europepmc   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres.

Human Reproduction, 2012
S. Simoens, G. Dunselman, C. Dirksen, L. Hummelshoj, A. Bokor, I. Brandes, V. Brodszky, M. Canis, G. Colombo, T. DeLeire, T. Falcone, B. Graham, G. Halis, A. Horne, Omar Kanj, J. Kjer, J. Kristensen, D. Lebovic, M. Mueller, P. Viganò, Marcel Wullschleger, T. D’Hooghe   +21 more
semanticscholar   +1 more source

Referral to low vision services by ophthalmologists

, 1996
Purpose: People in need of low vision rehabilitation services often experience delays in referral to services. This study investigated referral criteria of Australian ophthalmologists, the frequency of referral of their patients with low vision and ...
Lovie-Kitchin, Jan E., Taylor, Hugh R., Keeffe, Jill E.   +2 more
core  

Referral and management patterns for paediatric otorrhoea across primary and secondary care: a multicentre retrospective cohort study. [PDF]

Prim Health Care Res Dev
Heward E, Collingwood A, Jeffry F, Agrawal S, Jayaram S, Ashcroft DR, Hay AD, Nichani JR, Bruce IA.   +8 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source