Results 61 to 70 of about 2,702,060 (265)
A Refined Evaluation Function for the MinLA Problem [PDF]
, 2006 This paper introduces a refined evaluation function, called Φ, for the Minimum Linear Arrangement problem (MinLA). Compared with the classical evaluation function (LA), Φ integrates additional information contained in an arrangement to distinguish arrangements with the same LA value.
Eduardo Rodriguez-Tello +2 more
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Projectable Multivariate Refinable Functions and
, 2002 A biorthogonal wavelet is derived from a pair of biorthogonal refinable functions using the standard technique in multiresolution analysis. In this paper, we introduce the concept of projectable refinable functions and demonstrate that many multivariate ...
Biorthogonal Wavelets, Bin Han
core
On the regularity of refinable functions [PDF]
, 2006 Thesis (MSc (Mathematical Sciences. Physical and Mathematical Analysis))--University of Stellenbosch, 2006.This work studies the regularity (or smoothness) of continuous finitely supported refinable functions which are mainly encountered in ...
Onwunta, Akwum A.
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Generalized refinable maps and images of FANR's [PDF]
, 1991 In this paper we study certain shape and homotopy properties of refinable and weakly refinable maps. In particular we give a sufficient condition for a weakly refinable map to be a homotopy domination when the codomain is an ANR.
Rodríguez Sanjurjo, José Manuel +5 more
core +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source