Results 61 to 70 of about 10,103 (267)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Xylan extraction of bagasse pith in bio-refinery approach [PDF]
علوم محیطی, 2018 Introduction: Nowadays, pulp and paper industries, due to limitations in raw material supplying, Inefficiencies in achieving the system of producing multiple valuable products, the loss of large portion of raw material during processing, and also ...
Seyyedeh Sheyda Shafiei Amreie +3 more
doaj
بهداشت کار و ارتقای سلامت, 2022 Introduction: The main purpose of this research is modeling based on PHAST software, and achieving safe distances for deploying firefighting teams at the time of accidents as consequences of leakage, fire and explosion in some of the process equipment of
Mahdi JAFARI +2 more
doaj
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Outdoor investigation of air quality around Bandar Abbas - Iran oil refinery
International Journal of Environmental Health Engineering, 2012 Aims: This study has been conducted to assess air pollution, with respect to particulate matter less than 10 μm in diameter (PM 10 ), sulfur dioxide (SO 2 ), carbon monoxide (CO), nitrogen dioxide (NO 2 ), hydrogen sulfide (H 2 S), and the Air Quality ...
Mehdi Zare +6 more
doaj
Environmental Research LettersCritical energy infrastructure along the US Gulf Coast faces hurricane induced risks. While many studies assess the realized impacts of hurricane strikes, less attention has been paid to the economic consequences of anticipatory responses. Using 25 years
Yayun Chen +4 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source