Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Theoretical investigation of measuring cerebral blood flow in the adult human head using bolus indocyanine green injection and near-infrared spectroscopy [PDF]
To investigate the accuracy of measuring cerebral blood flow (CBF) using a bolus injection of indocyanine green (ICG) detected by near infrared spectroscopy in adult human heads, simulations were performed using a two layered model, representing the ...
Tachtsidis, I +11 more
core
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Biocompatible materials based on synthetic apatites co-doped with silver and lutetium ions
Apatite based (CaHap and CaFap) materials were synthesized by saline–melt method at moderate temperature. Their structure and composition have been studied by X-ray phase analysis (XRPA) and IR spectroscopy of diffuse reflectance.
Zinchenko, V. +2 more
doaj
Spectroscopic analysis of Pu-bearing compounds in double-walled cells
Spectroscopic analysis of radiological materials has been historically limited to radiological labs with older or less advanced scientific instrumentation. The development of double-walled cells (DWCs) at the Savannah River National Laboratory (SRNL) has
Eliel Villa-Aleman +5 more
doaj +1 more source
L'authentification rapide des poulets de chair sous label: distinction entre poulets issus de souches à croissance lente ou rapide par la spectrometrie dans le proche infrarouge. Analytical methods for the authentification of agro-food products. Gembloux (Belgium). 20 Oct 1999 [PDF]
Rapid authentification of certified chicken meat: distinguishing slow and fast growing chicken strains using near infrared reflectance spectroscopy.
Fumiere O., Sinnaeve G., Dardenne P.
doaj
Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito +7 more
wiley +1 more source
The non-invasive quantification of cutaneous haemoglobin and its oxygenation by reflectance spectrophotometry [PDF]
The work detailed in this study describes the design of a rapid scanning multiwavelength reflectance spectrophotometer and its application to the measurement of cutaneous pigments.
Hajizadeh-Saffar, Mohsen
core
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Adenosine triphosphate as a modulator of protein interactions and stability
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source

