Results 51 to 60 of about 318,464 (268)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

On Act-Types and Act-Tokens: or, the Distinction between Practical Reason and Practical Judgment in Kant

Journal of Modern Philosophy
While there is an extensive literature on Kant’s conception of practical reason, there is comparatively little on his conception of practical judgment. In addition, commentators have yet to take up the question of what the distinction between practical ...
Nicholas Dunn
doaj   +2 more sources

Analysis of the extension behavior of reflective cracks in asphalt pavements based on dry shrinkage property

SN Applied Sciences, 2022
In order to study the extension behavior of dry shrinkage type reflective cracks in asphalt pavements, this paper uses the differential equation theory to derive the calculation formula for the inhomogeneous gradient distribution of dry shrinkage stress ...
Min Min Xiao, Lin Fan
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

STEM Students’ Perceptions of Classical Reading: A Q-Methodology Study on Well-Being-Related Experiences

Behavioral Sciences
This study used the Q methodology to examine how Korean science, technology, engineering, and mathematics (STEM) students perceive the experience of reading classical texts and how such experiences relate to their overall well-being.
Yeonsook Kim, Song Yi Lee, Mikyung Jun, Taeeun Shim   +3 more
doaj   +1 more source

Reflection states in Ding-Iohara-Miki algebra and brane-web for D-type quiver

Journal of High Energy Physics, 2017
Reflection states are introduced in the vertical and horizontal modules of the Ding-Iohara-Miki (DIM) algebra (quantum toroidal gl1 $$ \mathfrak{g}{\mathfrak{l}}_1 $$).
J.-E. Bourgine, M. Fukuda, Y. Matsuo, R.-D. Zhu   +3 more
doaj   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Reflection-Type Phase Shifters Using RF-MEMS-Switched Bandpass Filtering Loads

IEEE Access
This manuscript reports on the design and practical development of reflection-type phase shifters (RTPSs) utilizing RF-switched bandpass filter (BPF)-based reflective loads.
Zehan Guo, Padraig Fitzgerald, Dimitra Psychogiou   +2 more
doaj   +1 more source