Results 91 to 100 of about 546,155 (300)

Early Spatial and Contextual Coding Deficits in Hippocampal CA1 Precede Performance Decline in an Alzheimer's Disease Model

Advanced Science, EarlyView.
Two‐photon calcium imaging in behaving 5xFAD mice reveals early CA1 coding deficits before behavioral decline. Task‐related place cell activity and splitter cell trajectory coding are impaired, with reduced retrospective dominance and greater prospective weighting.
Yimei Li, Mary Ann Go, Hualong Zhang, Robertas Aleksynas, Juliana Kim, Mingyang Gao, Seigfred Prado, Magdalena Sastre, Simon R. Schultz   +8 more
wiley   +1 more source

Whole body vibration of different frequencies inhibits H-reflex but does not affect voluntary activation [PDF]

, 2018
This study aimed to investigate the effects of whole-body vibration (WBV) at a frequency spectrum from 20 to 50 Hz on the Hoffmann (H) reflex and the voluntary motor output of ankle plantar-flexor muscles.
Orlando, Giorgio, Macaluso, Andrea, Sacchetti, Massimo, Laudani, Luca, Menotti, Federica, Mira, José, Pigozzi, Fabio, Carlucci, Flaminia, Giombini, Arrigo   +8 more
core   +1 more source

Beyond Biomimetics: Pathology‐Informed Engineering Rescues Reconstituted HDL From Inflammatory Dysfunction for Sepsis Immunotherapy

Advanced Science, EarlyView.
A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou, Lei Zhang, Xingyu Cai, Jiajia Su, Guangyu Dai, Xue Chen, Hanming Wang, Jia Hua, Jianping Liu, Chunmeng Sun, Xiancheng Chen, Erhao Wang, Wenli Zhang   +12 more
wiley   +1 more source

Expanded Phenotype Associated With an Intronic PPP1R12A Variant: A Case Report and Literature Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal dominant PPP1R12A‐related genitourinary and/or brain malformation syndrome is a recently described multisystem disorder caused by loss‐of‐function variants in the protein phosphatase 1 regulatory subunit 12a (PPP1R12A) gene. To date, 22 affected individuals have been reported with variable brain malformations and genitourinary ...
Emily M. Bland, Amber Nakar Weinstein, Eric C. Kao, Xiaonan Zhao, Monika Weisz‐Hubshman   +4 more
wiley   +1 more source

Spasticity mechanisms - for the clinician

Frontiers in Neurology, 2010
Spasticity, a classical clinical manifestation of an upper motor neuron lesion, has been traditionally and physiologically defined as a velocity dependent increase in muscle tone caused by the increased excitability of the muscle stretch reflex ...
Ambar eChakravarty, Angshuman eMukherjee
doaj   +1 more source

An abnormal neural reflex plays a role in causing syncope in sinus bradycardia [PDF]

, 1993
Objectives. This study Investigates the rote of an abnormal neural reflex in causing syncope in patients with sinus bradycardia.Background. Syncope is commonly considered an indication of severity in sinus bradycardia.
Paparella, Nelly, Oddone, Daniele, Alboni, Paolo, Menozzi, Carlo, Brignole, Michele, Dinelli, Maurizio, Lolli, Gino   +6 more
core   +1 more source

PUS7 Deficiency: Phenotypical Expansion of PUS7‐Related Neurodevelopmental Disorders

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Pathogenic variants in PUS7, encoding pseudouridine synthase 7, cause a rare neurodevelopmental disorder marked by intellectual disability, microcephaly, short stature, and behavioral disturbances. Since the first report in 2018, only 16 patients have been described.
Alice Muda, Barbara Belmessieri, Patrizia Accorsi, Jessica Galli, Edoardo Errichiello, Lucio Giordano   +5 more
wiley   +1 more source

Clinical use of vestibular evoked myogenic potential in migraine

Chinese Journal of Contemporary Neurology and Neurosurgery, 2010
Objective To assess migraineurs' vestibular function and reflex pathway of occular⁃brainstem⁃cervical muscle by recording and analysing vestibular evoked myogenic potential (VEMP), and discuss the VEMP clinical value.
Yan⁃e GUO, Sheng⁃yuan YU, Zi⁃ming WU   +2 more
doaj  

Clinical comparative study on the timing of tracheotomy in elderly neurocritically ill patients following craniotomy

Chinese Journal of Contemporary Neurology and Neurosurgery
Objective To investigate the factors influencing the timing of tracheostomy in elderly neurocritically ill patients following craniotomy. Methods Total 113 patients aged≥60 years who underwent tracheostomy after craniotomy at Beijing Tiantan Hospital ...
YANG Tao, ZHAO Jing-wei
doaj   +1 more source

Severe Phenotype in an Indian Family With Progressive Pseudorheumatoid Arthropathy of Childhood

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Progressive pseudorheumatoid arthropathy of childhood (PPAC) is a rare autosomal recessive progressive condition that affects the cartilage of joints and bones. The symptoms of PPAC include stiffness of the joints, bony swelling of the toes and fingers, short stature, kyphosis, and muscle weakness.
Narinder Singh, Arpita Neogi, Liliane H. Gibbs, Jagdish Soni, Elizabeth Chao, Virginia Kimonis   +5 more
wiley   +1 more source