Results 61 to 70 of about 66,431 (275)

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Hot Water Epilepsy in Children: A Rare Form of Reflex Epilepsy [PDF]

Aim: We evaluated the clinical and electroencephalography (EEG) characteristics, treatments, and outcomes of children with hot-water epilepsy (HWE), a specific type of reflex epilepsy. Materials and Methods: This retrospective study included 11 children
Ayfer Arduç Akçay, Serap Uysal
core   +1 more source

Abnormal blink reflex recovery cycle in manifesting and nonmanifesting carriers of the DYT1 gene mutation [PDF]

, 2016
The aim of this study is to evaluate the brainstem function in DYT1 carriers manifesting clinical dystonia (MDYT1) and those without clinical symptoms (NMDYT1).
Lu, C-S, Fong, P-Y, Edwards, MJ, Bhatia, KP, Huang, Y-Z, Rothwell, JC, Chen, R-S   +6 more
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

[Abnormalities in cough reflex].

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 1991
Enzymes degrading peptides may participate in the regulation of the cough reflex. Thus, decreases in enzyme activities may enhance cough reflex and a decrease in cough reflex may lead to aspiration pneumonia. Down- and up-regulation of cough reflex is important for the understanding of cough reflex.
K, Sekizawa, Y, Ujie, H, Nakazawa, H, Sasaki, U, Katsumata, R, Takasugi   +5 more
openaire   +1 more source

Abnormalities of Renal Function and Circulatory Reflexes in Primary Aldosteronism [PDF]

Circulation, 1966
The renal response to intravenous administration of isotonic saline solution and circulatory reflex reactivity was studied in nine patients with primary aldosteronism before and after surgical removal of an adrenal adenoma. In preoperative tests, infusion of saline was followed by abnormally rapid renal excretion of sodium and water, such as occurs in ...
E G, Biglieri, M B, McIlroy
openaire   +2 more sources

Abnormal reflex activation of hamstring muscles in dogs with cranial cruciate ligament rupture

, 2013
The mechanisms underlying cranial cruciate ligament rupture (CCLR) in dogs are poorly understood. In this study hamstring muscle reflexes in response to cranial tibial translation were analysed to determine whether these active stabilisers of the stifle ...
Langley-Hobbs, Sorrel J, jeffery, ND, Granger, Nicolas, Hayes, GM   +3 more
core   +1 more source

SERS Facemask for Rapid and Portable Sensing Mycobacterium Tuberculosis Antigens for TB Screening

Advanced Science, EarlyView.
Our study introduced an Au─Ag embedded covalent organic framework (U@COF) ‐mediated facemask for sensing TB antigen ESAT‐6/CFP‐10 complex in clinical droplet samples toward TB screening. Practical analysis of clinical samples demonstrated the availability of our facemask, which is capable of identifying the TB subjects (N = 17) from healthy candidates (
Lingzhi Chen, Jiaqi Yu, Jing Xu, Lingqi Chen, Ninghao Zhang, Wenrui Li, Runmin Zeng, Xiaomin Luo, Yiqun Chang, Jiayin Lai, Wenshi Huang, Xiaochen Liang, Ting Zhao, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Xueqin Huang, Haibo Zhou, Junxia Zheng   +20 more
wiley   +1 more source

Exercise pressor reflex in health and diseases: Animal studies

Journal of Physical Fitness and Sports Medicine, 2015
A reflex originating in exercising skeletal muscle contributes to sympathoexcitation during exercise. This muscle-based reflex is termed the exercise pressor reflex (EPR).
Satoshi Koba
doaj   +1 more source

The sensitivity and specificity of the neurological examination in polyneuropathy patients with clinical and electrophysiological correlations. [PDF]

PLoS ONE, 2017
INTRODUCTION:Polyneuropathy is one of the most prevalent neurologic disorders. Although several studies explored the role of the neurological examination in polyneuropathy, they were mostly restricted to specific subgroups of patients and have not ...
Alon Abraham, Majed Alabdali, Abdulla Alsulaiman, Hana Albulaihe, Ari Breiner, Hans D Katzberg, Danah Aljaafari, Leif E Lovblom, Vera Bril   +8 more
doaj   +1 more source