Results 41 to 50 of about 8,870 (266)

Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway

Advanced Science, EarlyView.
Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen, Yao Zhao, Yangye Lian, Yifei Hou, Lifen Gong, Tingting Wu, Yulin Yang, Jiaqi Zhu, Xin Wang, Kaihua Zhang, Jing Ding   +10 more
wiley   +1 more source

Versatility of Fear-potentiated Startle Paradigms for Assessing Human Conditioned Fear Extinction and Return of Fear

Frontiers in Behavioral Neuroscience, 2011
Fear conditioning methodologies have often been employed as testable models for assessing learned fear responses in individuals with anxiety disorders such as post-traumatic stress disorder (PTSD) and specific phobia.
Seth Davin Norrholm, Kemp M Anderson, Ilana W Olin, Tanja eJovanovic, Cliffe eKwon, Victor T Warren, Alexander eMcCarthy, Lauren eBosshardt, Justin eSabree, Justin eSabree, Erica J Duncan, Barbara O Rothbaum, Bekh eBradley   +12 more
doaj   +1 more source

Prepulse Inhibition of the Auditory Startle Reflex Assessment as a Hallmark of Brainstem Sensorimotor Gating Mechanisms

Brain Sciences, 2020
When a low-salience stimulus of any type of sensory modality—auditory, visual, tactile—immediately precedes an unexpected startle-like stimulus, such as the acoustic startle reflex, the startle motor reaction becomes less pronounced or is even abolished.
Ricardo Gómez-Nieto, Sebastián Hormigo, Dolores E. López   +2 more
doaj   +1 more source

“It's Not Deterministic and It Will Never Be Deterministic”: A Qualitative Study on Stakeholder Perspectives of Polygenic Risk Score Testing for Post‐Traumatic Stress Disorder

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Post‐traumatic stress disorder (PTSD) causes significant mental and physical distress, yet only a small subset of individuals exposed to trauma develop the disorder. Scientists and clinicians are still unable to predict who will get the disorder or how it will manifest.
Brandy M. Fox
wiley   +1 more source

A psychophysiological investigation of laterality in human emotion elicited by pleasant and unpleasant film clips

Annals of General Psychiatry, 2010
Background Research on laterality in emotion suggests a dichotomy between the brain hemispheres. The present study aimed to investigate this further using a modulated startle reflex paradigm.
Kumari Veena, Kaviani Hossein, Wilson Glenn D   +2 more
doaj   +1 more source

Machine learning, waveform preprocessing and feature extraction methods for classification of acoustic startle waveforms

MethodsX, 2021
The acoustic startle response (ASR) is an involuntary muscle reflex that occurs in response to a transient loud sound and is a highly-utilized method of assessing hearing status in animal models.
Timothy J. Fawcett, Chad S. Cooper, Ryan J. Longenecker, Joseph P. Walton   +3 more
doaj   +1 more source

On the Prospects for African Philosophy in Australia

Australian Journal of Social Issues, EarlyView.
ABSTRACT This paper grapples with the situation of people of African descent in Australia by working through the constitution of the body of academic philosophy in the country. It contends with the parochialism of the Australian philosophical community and the prospects for the cultivation of greater pluralism. Taking African philosophy as one possible
Bryan Mukandi
wiley   +1 more source

Psychophysiological responses to facial expression of surprise, sadness, and disgust

Australian Journal of Psychology, 2019
Objective The aim of the present study was to evaluate psychophysiological responses to expressions of surprise, sadness, and disgust and the possible effect of the expresser's sex.
Carlos Gantiva, Andrés Araujo, Luz Calderón, Paola Gómez, Fernando Reina   +4 more
doaj   +1 more source

Subcellular Dissection of a Simple Neural Circuit: Functional Domains of the Mauthner-Cell During Habituation

Frontiers in Neural Circuits, 2021
Sensorimotor integration is a pivotal feature of the nervous system for ensuring a coordinated motor response to external stimuli. In essence, such neural circuits can optimize behavioral performance based on the saliency of environmental cues.
Dániel Bátora, Áron Zsigmond, István Z. Lőrincz, Gábor Szegvári, Máté Varga, András Málnási-Csizmadia, András Málnási-Csizmadia   +6 more
doaj   +1 more source

Australian Activists as Storytellers in Digital Spaces: Acquiring Skills, Producing Content and Getting the Message Out

Australian Journal of Social Issues, EarlyView.
ABSTRACT As modes of activism rapidly evolve, activists—both seasoned and emerging—must increasingly navigate a hybrid terrain of both digital and non‐digital engagement. This paper draws on the personal narratives of 16 nascent activists based in Australia to explore how they develop competencies related to digital storytelling, which is critical to ...
Garth Stahl, Miri Yemini, Claire Maxwell, Yating Hu, Benjamin Adams, Sarah Bergen   +5 more
wiley   +1 more source