Results 161 to 170 of about 15,581 (263)

Monoallelic POLR3A Variants Cause Early‐Onset Peripheral Neuropathy

Annals of Neurology, EarlyView.
Objective Biallelic variants in genes encoding the RNA polymerase III complex (Pol III) cause a spectrum of neurological disorders primarily affecting the central nervous system. Monoallelic variants have been reported in the POLR3B subunit only, associated with neurodevelopmental disorder, epilepsy, and peripheral neuropathy.
Luiza L. P. Ramos, Jevin M. Parmar, Robin Wijngaard, Bianca R. Grosz, Tamas Lazar, Ligia Mateiu, Steve Vucic, Kishore R. Kumar, Dennis Yeow, Laura I. Rudaks, Lonneke de Boer, Annemarie de Vreugd, David A. Koolen, Thatjana Gardeitchik, Anita Cairns, Krishnan Iyengar, Fernando Kok, Fernanda Barbosa Figueiredo, Alzira Alves de Siqueira Carvalho, Luiz S. Mageste Barbosa, Rodrigo Rezende Arantes, Tyler Rehbein, Jordan E. Bontrager, Elizabeth P. Wood, Janet E. Sowden, Gavin Monahan, Meutia Kumaheri, Ivy Cuijt, Melina Ellis, Gonzalo Perez‐Siles, Elyshia McNamara, Ronald van Beek, Celine B. Meijers, Ivaylo Tournev, Stephan Zuchner, Shoshana J. Wodak, Clara D. M. van Karnebeek, Nigel Laing, Liana N. Semcesen, David A. Stroud, David N. Herrmann, Velina Guergueltcheva, Marina L. Kennerson, Machteld M. Oud, Gianina Ravenscroft, Ayse Candayan, Albena Jordanova   +46 more
wiley   +1 more source

Reflex Charging for Anion‐Derived Solid Electrolyte Interphase Formation

Angewandte Chemie, EarlyView.
Reflex charging reprograms the electric double layer (EDL) during battery formation by periodically reversing electrode polarity, enabling persistent anion enrichment at the interface. This dynamic interfacial control shifts Li+ solvation toward anion‐coordinated states, promoting the formation of an inorganic‐rich, anion‐derived solid electrolyte ...
Gyeoul Seong, Min‐Gyun Kim, Eunyeong Jung, Yerin Kang, Hong‐I Kim, Kwon‐Hyung Lee, Kohei Shimokawa, Won Bo Lee, Sang‐Young Lee, Seung‐Hyeok Kim   +9 more
wiley   +2 more sources

Neurophysiological and Structural-Mechanical Changes Associated with Dry Needling in Post-Stroke Spasticity: A Systematic Review. [PDF]

J Clin Med
Eeckhaut B, Truijen S, Leroij C, Dévillé J, Jacobs L, Saeys W.   +5 more
europepmc   +1 more source

Diabetes and the Metabolic Syndrome as Drivers of Neurodegeneration: Convergent Mechanisms Linking Peripheral Neuropathy and Dementia

Annals of Neurology, EarlyView.
The metabolic syndrome, a state of progressive metabolic dysfunction, injures the peripheral and central nervous systems, promoting peripheral neuropathy (PN) and cognitive impairment (CI), respectively. We posit PN and CI are connected in the metabolic syndrome framework, built on the premise that neurons, whether in the peripheral or central nervous ...
Masha G. Savelieff, David L. Bennett, Troels S. Jensen, Eva L. Feldman   +3 more
wiley   +1 more source

Tailoring Photochromism Beyond Human Eye Visibility: On/Off Switchable NIR Absorption in an Aluminosilicate

Angewandte Chemie, EarlyView.
A new photochromic material was developed. Its on/off‐switchable absorption band is situated completely outside the human eye's visibility, in the near‐infrared (NIR) region, a feature never reported before. The photochromism mechanism in this aluminosilicate is elucidated by combining experimental as well as computational results, and the material's ...
Bettiina Muurinen, Hannah Byron, Teppo Kreivilä, Roosa Vastamäki, Sami Vuori, Tomasz Galica, Ian P. Machado, Sari Granroth, Basit Ali, Maarit Karppinen, Ivo Heinmaa, Milica Todorović, Raphael Rullan, Stephan Steinmann, Tangui Le Bahers, Mika Lastusaari   +15 more
wiley   +2 more sources

Maternal‐Fetal Administration of Risdiplam Partially Rescues the SMNΔ7 Mouse Model of Spinal Muscular Atrophy

Annals of Neurology, EarlyView.
Objective Spinal muscular atrophy (SMA) is caused by deletions or mutations in the survival motor neuron 1 (SMN1) gene and subsequent reduction in the expression of survival motor neuron (SMN) protein. The disease is characterized by degeneration of α motor neurons and subsequent muscle atrophy.
Emma R. Sutton, Ariane Beauvais, Rebecca Yaworski, Hugh J. McMillan, Rashmi Kothary   +4 more
wiley   +1 more source

GsMTx-4 inhibits the exercise pressor reflex and the muscle mechanoreflex primarily through TRPC inhibition. [PDF]

J Physiol
Ducrocq GP, Anselmi L, Brandt K, Wang J, Velasco VR, Kaufman MP.   +5 more
europepmc   +1 more source

Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3

Annals of Neurology, EarlyView.
Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato, John M. Hayes, Jacen Emerson, Maeha Sridharan, Toluwani Adelaja, Arsal Naeem, Alexandra F. Putka, Hayley S. McLoughlin   +7 more
wiley   +1 more source

Vagal blood volume receptors compensate for haemorrhage and posture change. [PDF]

Nature
Liu Z, Lu S, Haskell IA, Schappe MS, Josipović M, Min S, Alabi AA, Chi J, Kim M, Liberles SD.   +9 more
europepmc   +1 more source

Speed Matters: Challenging the Notion of Velocity-Independent Rigidity Using Technological Devices in People with Parkinson's Disease: A Systematic Review. [PDF]

Neurol Int
Cano-de-la-Cuerda R, Estrada-Barranco C, Martín-Casas P, Marcos-Antón S, Ortiz-Gutiérrez RM, Laguarta-Val S, Jiménez-Antona C.   +6 more
europepmc   +1 more source