Results 111 to 120 of about 271,820 (266)

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury

Advanced Science, EarlyView.
A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin, Yuan Jiang, Yongheng Xie, Huanwei Qu, Wenbin Yan, Jingle Chen, Yining Chen, Huayi Li, Naibo Feng, Jiajun Wu, Chao Zhang, Zhengqi Huang, Ming Shi, Zhihuai Deng, Guozhi Xiao, Houqing Long   +15 more
wiley   +1 more source

Screening Impact of Anti-HDV Reflex Testing Among HBsAg-Positive Individuals. [PDF]

J Clin Med
Regev-Sadeh T, Neeman Z, Schwartz N, Rozenberg O, Abu Baker F, Saadi T, Tatour M, Hazzan R.   +7 more
europepmc   +1 more source

THE APPENDIX REFLEX [PDF]

BMJ, 1927
openaire   +2 more sources

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Temporal shift in task factor influence across the stretch reflex. [PDF]

PLoS One
Torell F, Rohlén R, Dimitriou M.
europepmc   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

A portable closed-loop platform enabling cortical evoked potential operant conditioning: system development and validation of target intensity estimation. [PDF]

Biomed Phys Eng Express
Gupta D, Brangaccio J, Mojtabavi H, Hill NJ.   +3 more
europepmc   +1 more source

Palmomental reflex and palmosubmental reflex

, 2008
Amaç ve hipotez: Palmomental refleks yanıtı ilkel bir refleks olarak düşünülür ve patolojik durumlarla ilişkilidir. Sağlıklı yaşlılar ve demansif hastalarda, median sinir uyarımı ile mental ve submental kasların refleks aktivasyonu daha önce ...
Uğurel, Burcu
core  

Synthesis and Characterization of Highly Conductive Cobalt Phthalocyanine‐Based Metal–Organic Framework

Advanced Electronic Materials, EarlyView.
A two‐dimensional (2D) layered material, CoPc‐MOF, with a cobalt phthalocyanine backbone as its structural unit, was successfully synthesized. CoPc‐MOF adopts a crystal structure analogous to a Lieb lattice, which is a type of Dirac material. CoPc‐MOF exhibits exceptionally high electrical conductivity for an organic semiconductor, which likely ...
Norihiro Morishita, Momoka Isobe, Fumiya Abe, Ayaka Yasuda, Kenichi Ozawa, Kazuhiko Mase, Ryosuke Ohnuki, Shinya Yoshioka, Kaname Kanai   +8 more
wiley   +1 more source