Results 161 to 170 of about 339,743 (245)

Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice

Advanced Science, EarlyView.
CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Jie Zhu, Xi‐xiu Xie, Lei Li, Chen Tian, Hao‐tian Wang, Xiao‐jie Wang, Xiao‐lin Yu, Gui‐feng Zhang, Rui‐tian Liu   +8 more
wiley   +1 more source

A Clinical Workflow for Evaluating Dose to Organs at Risk After Biology-Guided Radiation Therapy Delivery. [PDF]

Cancers (Basel)
Banks TI, Shen C, Godley AR, Park YK, Prasad R, Ravikiran M, Badiyan SN, Dan T, Garant A, Timmerman R, Jiang S, Cai B.   +11 more
europepmc   +1 more source

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

SARS-CoV-2 mRNA Vaccination Improved Survival in NSCLC Treated With Radiotherapy. [PDF]

J Thorac Oncol
Xu X, Saad MB, Grippin A, Xu H, Muneer A, Young E, Lin SH, Liao Z, Gandhi S, Balter P, Ning MS, Qian D, Bronk JK, Chen A, O'Reilly M, Nguyen QN, Welsh J, Pollard-Larkin JM, Heymach JV, Lee JJ, Wu J, Chang JY.   +21 more
europepmc   +1 more source

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

Advanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin, Jiani Li, Panqin Ma, Shinan Wu, Wenying Guan, Yimin Huang, Ke Feng, Mingyan Wei, Zixuan Yang, Shujia Guo, Caihong Huang, Yun‐Long Wu, Yi Han, Zuguo Liu   +13 more
wiley   +1 more source

Evaluation of treatment planning feasibility of a positron emission tomography (PET)-Linac system for spine stereotactic body radiotherapy (SBRT). [PDF]

J Appl Clin Med Phys
Zhang H, Yan S, Peng H, Banks T, Prasad R, Park YK, Godley A, Cai B, Shen C.   +8 more
europepmc   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

Chest wall heterotopic ossification causing restrictive physiology after resuscitative thoracotomy and surgical stabilization of rib fractures: a report and review. [PDF]

Trauma Surg Acute Care Open
Knight AW, Anderson M, Rahimy E, Forrester J.   +3 more
europepmc   +1 more source

Controlling Self‐Doping in Conjugated Polyelectrolyte Copolymers to Vary the Threshold Voltage in OECTs

Advanced Electronic Materials, EarlyView.
Two series of self‐doped conjugated polyelectrolytes are synthesized from a non‐self‐dopable building block 3MEEET and a self‐dopable building‐block 3HOT−[TMA+] or 3HOT−[SO3H] enabling precise control over the degree of self‐doping, which in turn directly governs the threshold voltage (VT) in OECTs over a wide range of 700 mV.
Julian Hungenberg, Andreas W. Erhardt, Adrian Hochgesang, John Mohanraj, Lys Sprenger, Sahar Salehi, Christopher R. McNeill, Mukundan Thelakkat   +7 more
wiley   +1 more source

Key aspects of nursing practice that underpin certain discourses: an integrative review. [PDF]

Rev Bras Enferm
Macías MLC, Basurto SDÁ, Zambrano JAR, Quiroz JTG.   +3 more
europepmc   +1 more source