Results 231 to 240 of about 248,421 (302)

Stepwise Synthesis of Tetrabenzotriazaporphyrins (TBTAPs) and Their Open 2‐ and 3‐Ring Fragments

open access: yesChemistry – A European Journal, EarlyView.
Unexpected reaction pathways to porphyrin‐phthalocyanine hybrids are uncovered by the synthesis of “half‐macrocycle” fragments and subsequent macrocyclization. Rather than the expected 2:2 “ABBA” product, the 3:1 “ABBB” hybrid is isolated as the only macrocyclic product.
Jacob Gretton   +10 more
wiley   +1 more source

A Unified Approach for the Synthesis of Conformationally Locked and sp2‐sp3 Fused Hybrids

open access: yesChemistry – A European Journal, EarlyView.
This study presents a systematic platform to build rigid sp2–sp3 hybrids via benzyne cycloadditions. Arene‑fused bicyclic oxa‐, aza‐, and carbocycles are converted into medicinally relevant amino acids and applied to Enalapril analogues synthesis. The hybrids combine aromatic interactions with 3D rigidity, tuning lipophilicity, pKa, and solubility ...
Ervis Saraci   +8 more
wiley   +1 more source

Introduction of a Double‐Headed Nucleotide Into G‐Quadruplex DNA: Position‐Dependent Stabilization and Structural Insights

open access: yesChemistry – A European Journal, EarlyView.
A double‐headed bis‐guanine (G) nucleotide (GG) was evaluated as a noncanonical building block in G‐quadruplexes (G4s). Biophysical and computational analyses reveal that GG can directly participate in G‐tetrads and strongly stabilize G4s in a position‐ and topology‐dependent manner. These findings establish design rules for using GG to engineer highly
Krista Urup   +5 more
wiley   +1 more source

Vietnam Association of Gastroenterology (VNAGE) guideline on the management of gastroesophageal reflux disease. [PDF]

open access: yesFront Med (Lausanne)
Dao HV   +27 more
europepmc   +1 more source

Benzo[c][1,2,5]Thiadiazole Linkers Enhance the Effectiveness of Cavity‐Containing Supramolecular Photocatalysts

open access: yesChemistry – A European Journal, EarlyView.
Seven novel supramolecular photosensitizers based on benzo[c][1,2,5]thiadiazole (BTZ) tethered to calix[4]arene (C[4]) scaffolds are reported with facile, scalable, and selective syntheses. Their abilities to produce singlet oxygen have been tested through the photo‐oxidation of α‐terpinene.
Leonardo Amicosante   +6 more
wiley   +1 more source

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