Results 91 to 100 of about 186,932 (199)

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Brain‐Adhesive Bioelectronics With Shape‐Morphable and Biodegradable Properties for Stable Brain Signal Monitoring

Advanced Science, EarlyView.
A brain‐adhesive sensor (B‐Sensor) was developed by integrating a self‐healing biodegradable elastomer, a tissue‐adhesive hydrogel, and molybdenum electrodes. The B‐Sensor adheres to brain tissue, conforms to cortical curvatures, and maintains stable electrical performance over the intended period for reliable recording of spatiotemporal brain activity
Heewon Choi, Soeun Kim, Sumin Kim, Jaehyun Park, Soojung An, Sungjun Yoon, Mikyung Shin, Sangho Cho, Donghee Son   +8 more
wiley   +1 more source

A Guide for Spatial Omics Technologies: Innovation, Evaluation, and Application

Advanced Science, EarlyView.
This review presents a strategy‐centric framework for spatial omics technologies, organizing methods by how spatial information is experimentally encoded. It compares key performance trade‐offs across sequencing‐ and imaging‐based approaches, examines computational and practical limitations, and highlights biomedical applications. The analysis provides
Xiaofeng Wu, Weize Xu, Da Lin, Leqiang Sun, Jinxia Dai, Gang Cao   +5 more
wiley   +1 more source

Skin‐Inspired Design of Self‐Healing Coatings Integrating Interface‐Liquid Repellency and Corrosion Resistance

Advanced Science, EarlyView.
A skin‐inspired multilayered coating system is developed to integrate multiple, often conflicting, functions of self‐healing capability, strong liquid repellency, long‐term corrosion resistance, and robust adhesion, to tackle diverse challenges in engineering services.
Bingzhi Li, Bingce Liu, Enyu Guo, Zhihao Zhou, Yibo Ouyang, Xiao‐Bo Chen, Huijun Kang, Zongning Chen, Tongmin Wang   +8 more
wiley   +1 more source

Review of books issued by Center for Promotion of Criminal Justice Reform to assist the specialists working with offenders

Психология и право, 2014
Russia's oldest human rights organization Center for Prison Reform Facilitation (founded in 1988) presents the results of its publishing activities addressed to professionals working in the field of socio-psychological and legal assistance to minors and ...
Dzyadko N. M.
doaj  

Highly Sensitive and Temperature‐Insensitive Stretchable Strain Sensor with Microcrack‐Engineered Architecture

Advanced Science, EarlyView.
This study proposes a stretchable strain sensor that demonstrates a high gauge factor of 2.3 × 104 and excellent linearity (R2 = 0.98), while maintaining temperature insensitivity under applied strain. This performance is achieved through a microcrack architecture formed by stacking a brittle, low‐resistance material with a stretchable, high‐resistance
Yu Kato, Kento Yamagishi, Kenjiro Fukuda, Takao Someya, Tomoyuki Yokota   +4 more
wiley   +1 more source

Regulating Solvent‐Separated Ion Pairs to Control Polysulfide Redox for Fast and Stable Room‐Temperature Na‐S Batteries

Advanced Science, EarlyView.
A local high‐concentration electrolyte with tailored solvent‐separated ion pairs is pioneered to design for room‐temperature sodium‐sulfur batteries. This electrolyte allows sparingly dissolved polysulfides and localizes them onto reactive interfaces for liquid‐solid conversion.
Xiang‐Long Huang, Xue Li, Hengjia Shao, Xinran Gao, Zhengzhao Huang, Lingfei Zhao, Long Yao, Kunjie Zhu, Fu‐Sheng Ke, Hua‐Kun Liu, Wei‐Hong Lai, Yun‐Xiao Wang   +11 more
wiley   +1 more source

The Enhanced Whey Protein Oral Bioavailability and Muscle Anabolism Ability by a Simple and Effective Piperine‐Whey Protein Synergistic Codelivery System

Advanced Science, EarlyView.
WP(Pip) is a mixture of whey protein and piperine‐loaded nanoemulsion stabilized by WP through microfluidic homogenization. Acting as a “smart key,” piperine opens epithelial tight junctions to enhance absorption of whey protein and, thereby increasing circulating amino acid availability, synergistically up‐regulates the mTOR signaling pathway in ...
Qing Yue, Kaiwen Wu, Bing Wei, Guiling Song, Congyu Sun, Xing Li, Xiangyu Liu, Zhaoxiang Ma, Mingchun Lv, Jasper Landman, Yuan Li   +10 more
wiley   +1 more source

Breaking the Toughness‐Stretchability Trade‐Off in Hydrogels with Dynamic Hydrogen Bonding

Advanced Science, EarlyView.
A novel nanocomposite hydrogel architecture overcomes the inherent conflict between toughness and stretchability by integrating uniformly dispersed aminopropyl‐hybrid‐phyllosilicate nanosheets within a polyacrylamide matrix. This design leverages a dynamic hydrogen‐bonding network to facilitate efficient energy dissipation and self‐recovery.
Yining Gao, Yong Tao, Roland J.‐M. Pellenq, Fazhou Wang   +3 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source