Results 181 to 190 of about 1,664,562 (341)

A Lipid with Lewis Pair‐Mediated Targeting and Multiple Stimuli‐Responsive Delivery of Antibiotics for Bacterial Infections

open access: yesAdvanced Science, EarlyView.
Lewis pair‐integrated lipids (Lp‐lipids), combining targeted delivery and stimuli‐responsive are developed for antibiotic delivery. These lipids form nanoparticles that bind biofilms via boronate ester bonds and respond to acidic pH, H2O2, and ATP, enabling controlled drug release.
Xiaojian Yan   +11 more
wiley   +1 more source

cGAS Inhibits ALDH2 to Suppress Lipid Droplet Function and Regulate MASLD Progression

open access: yesAdvanced Science, EarlyView.
cGAS is a cytosolic DNA sensor known for innate immune defense. cGAS binds and suppresses ALDH2 are showed, limiting acetyl‐CoA production. cGAS loss activates ALDH2, promoting histone acetylation, lipogenesis, and lipid droplets accumulation. cGas‐/‐ mice on a high‐fat diet show signs of worsened MASLD.
Ying Wang   +14 more
wiley   +1 more source

Real‐Time Detection of Reduced Nitroreductase with a Reversible Fluorescent Probe

open access: yesAdvanced Science, EarlyView.
The first reversible binding probe (rNTRp) is presented that selectively detects the nitroreductase enzyme's active, reduced form (red‐NTR) with a fluorescence turn‐on response. Contrary to the conventional reaction‐based probes known to date, which provide only static information on the accumulated enzyme activity at a given time, rNTRp allows ...
Sourav Sarkar   +8 more
wiley   +1 more source

The Role of Pharmacy Benefit Managers in Access to Biologics for Dermatologic Conditions. [PDF]

open access: yesJ Psoriasis Psoriatic Arthritis
Leeolou MC, Jia JL, Harris J, Liao W.
europepmc   +1 more source

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