Results 21 to 30 of about 967,211 (262)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Justification of the Thematic Legislation in Indonesia

Jurnal Konstitusi
The use of the omnibus method has been controversial since the enactment of the Job Creation Law due to its cross-sectoral nature, making the resulting legislation difficult for the public to understand.
Umbu Rauta, Titon Slamet Kurnia, Freidelino Paixao Ramos Alves de Sousa, Adérito de Jesus Soares, Marcelino Ceasar Kishan, Bernadeta Adriana Sandra Jeconiah   +5 more
doaj   +1 more source

Clinical and Modifiable Factors Associated With Disability and Relapse in MOGAD: A Multicentre Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Factors associated with relapse course and disability in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) remain incompletely understood. Objectives To identify clinical and modifiable factors associated with relapse and disability in MOGAD. Methods In this ambispective multicentre cohort study using data from
Yingtao Wang, Shaoxin Tao, Qiujia Wang, Xiaoyu Xu, Hui Yao, Zheng Liu, Dawei Li, Zhandong Qiu, Jinming Han, Jiangwei Xia, Qi Wang, Jun Sun, Kai Shao, Jiao Li, Shishuang Ruan, Yi Zhong, Jun Guo, Shougang Guo, Yue Huang, Guoliang Chai, Tao Jin, Hongyu Zhou, Junwei Hao, Yinan Zhao   +23 more
wiley   +1 more source

Retracted: Fast Recognition Method of Football Robot’s Graphics From the VR Perspective

IEEE Access, 2020
The purpose of this article is to identify football and related environmental variables through its VR images under the current situation where the vision system has become the only way for football robots to obtain the external environment, so as to ...
Zhen Bai, Liang Wang, Sheng Zhou, Yuan Cao, Ying Liu, Jie Zhang   +5 more
doaj   +1 more source

An Action Plan for the Restructuring and Rationalization of the National Intercity Rail Passanger System [PDF]

, 2002
Final report of the Amtrak Reform Council describing their activities and findings regarding the Council's proposed action plan for restructuring the national intercity rail passenger system in the face of Amtrak's failure to achieve operational self ...
Amtrak Reform Council
core  

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Assessing professional behaviors: a self-administered scale for medical students during clerkships

BMC Medical Education
Background Medical professionalism is a core competency for medical students during clerkships for further professional development. Given that the behavior-based framework could provide clear insight and is easy to assess, the study aimed to create a ...
Chunyu Xin, Xinzhi Song, Simeng Wang, Xuemei Cui, Ning Ding, Deliang Wen   +5 more
doaj   +1 more source

China's nuclear power under the global 1.5 °C target: Preliminary feasibility study and prospects

Advances in Climate Change Research, 2018
This study explores the measures to achieve the global 1.5 °C temperature rise target (1.5 °C target) by analyzing the feasibility and obstacles of nuclear power in China.
Xin-Jian Xiao, Ke-Jun Jiang
doaj   +1 more source

Superlubricity and Corrosion Inhibition Properties of Solvate Ionic Liquids in Hybrid Carbon Fiber Reinforced Plastic–Steel Interfaces

Advanced Engineering Materials, EarlyView.
Solvate ionic liquids lubrication reduced the coefficient of friction by ∼60% compared to dry sliding, reaching steady‐state values as low as 0.04–0.05. Corrosion weight‐loss measurements in 1 M HCl further demonstrated significant inhibition behavior, with only 100 ppm of [Li(G3)][TFSI] (∼68.5 μL/L) reducing corrosion‐product weight loss by 63 ...
Sameh Dabees, Timothy Harte, Bhagya Dharmasiri, Y. Athulya Wickramasingha, David J. Hayne, Daniel J. Eyckens, Luke C. Henderson   +6 more
wiley   +1 more source

Transforming public services

Administration
The public service works to provide frontline and vital services to meet the needs of the people of Ireland. Working on behalf of the government in a diverse range of organisations, public servants play an established role in the economic and social life
Moloney David, Dwyer Rowena, Glavey Sarah, Sellars Dermot   +3 more
doaj   +1 more source