Results 21 to 30 of about 454,267 (310)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Assessment of Sectoral Impacts Based on the Inter-Sectoral Regional Balance Model

open access: yesInformaciâ i Innovacii, 2019
In the presented article, the analysis and assessment were made through the regional intersectoral balance model for the Azerbaijani economy. Thus, based on official data provided by the State Statistical Committee of the Republic of Azerbaijan, a ...
E. Rustamov
doaj   +1 more source

Clinical and Modifiable Factors Associated With Disability and Relapse in MOGAD: A Multicentre Cohort Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Factors associated with relapse course and disability in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) remain incompletely understood. Objectives To identify clinical and modifiable factors associated with relapse and disability in MOGAD. Methods In this ambispective multicentre cohort study using data from
Yingtao Wang   +23 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem   +9 more
wiley   +1 more source

Superlubricity and Corrosion Inhibition Properties of Solvate Ionic Liquids in Hybrid Carbon Fiber Reinforced Plastic–Steel Interfaces

open access: yesAdvanced Engineering Materials, EarlyView.
Solvate ionic liquids lubrication reduced the coefficient of friction by ∼60% compared to dry sliding, reaching steady‐state values as low as 0.04–0.05. Corrosion weight‐loss measurements in 1 M HCl further demonstrated significant inhibition behavior, with only 100 ppm of [Li(G3)][TFSI] (∼68.5 μL/L) reducing corrosion‐product weight loss by 63 ...
Sameh Dabees   +6 more
wiley   +1 more source

View at the Reform of the Economy of Uzbekistan through the Prism of the Republic’s Cooperation with International Development Institutions

open access: yesПроблемы постсоветского пространства, 2022
The reforms carried out recently in the Republic of Uzbekistan have caused a wide discussion. For many, the speed with which the liberalization of the economy is carried out, as well as the scale of transformations, came as a surprise.
E. S. Romanchuk
doaj   +1 more source

Adaptive Foam 3D Printing of Ultralight and Multifunctional Materials

open access: yesAdvanced Engineering Materials, EarlyView.
Adaptive foam 3D printing, enabled by expandable microspheres, imparts cellular structures to thermoplastic and thermosetting polymers, manufactured through a variety of processes including fused filament fabrication, direct ink writing, digital light processing, and inkjet printing.
Nariman Rajabifar, Amir Ameli
wiley   +1 more source

Democratic anchorage through administrative reforms [PDF]

open access: yes
Published online: April 2025This note develops the concept of democratic anchorage as an analytical lens for assessing how administrative reforms contribute to the legitimacy of public governance.
KOVAREK, Dániel   +8 more
core   +1 more source

Challenges of the Path towards an Enlarged Europe: South Eastern Europe – Inequality and Social Exclusion [PDF]

open access: yesRomanian Journal of European Affairs, 2007
“Challenges of the path towards an enlarged Europe: South Eastern Europe” is a series of articles dedicated to support the improvement of the national strategies for mitigating poverty and promoting social inclusion.
Iulian Oneaşcă
doaj  

Assessing market competition in the Philippine cigarette industry

open access: yesTobacco Induced Diseases, 2018
Background The recent passage of the Philippine Competition Act has caused many to rethink the market structure of Philippine industries. Foremost is the cigarette industry, whose structure bear important implications on the health of Filipinos.
Meg Reganon, Madeiline Joy Aloria
doaj   +1 more source

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