Results 141 to 150 of about 2,878,418 (399)

PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid‐Induced Osteoporosis by Suppressing Osteocyte Ferroptosis

Advanced Science, EarlyView.
Glucocorticoid‐induced osteoporosis (GIOP) triggers osteocyte ferroptosis via SLC7A11 degradation. PSMD14 stabilizes SLC7A11 by counteracting glucocorticoid‐driven ubiquitination, preserving cystine uptake and glutathione synthesis. AAV‐mediated PSMD14 delivery or its agonist Pantethine rescues osteocyte survival and bone loss in GIOP mice.
Yifeng Shi, Qian Tang, Sunren Sheng, Hongyi Jiang, Chen Jin, Chencheng Zhou, Chenglong Xie, Lin Zheng, Di Zhang, Hui Xu, Cong Xu, Haiwei Ma, Guangheng Xiang, Wenfei Ni, Xiaoyun Pan, Lei Yang, Huazi Xu, Yu Qian, Aimin Wu, Xiangyang Wang, Gang Zheng   +20 more
wiley   +1 more source

Evaluating the Predictive Accuracy of an AI-Based Tool for Postoperative Vault Estimation in Phakic Intraocular Lens Implantation

Clinical Ophthalmology
Roger Zaldivar,1,* Roberto Zaldivar,1,* Arthur B Cummings,2,* Brendan K Cummings,2,* Erik LJG Mertens,3,* Robert Edward Ang,4,* Lucia Irupé Zarate Piscopo,1,5,* Gabriel Quintero,1,5,&ast ...
Zaldivar R, Zaldivar R, Cummings AB, Cummings BK, Mertens EL, Ang RE, Zarate Piscopo LI, Quintero G, Cerviño A   +8 more
doaj  

Obesity negatively impacts corneal nerves in patients with diabetes mellitus

Eye and Vision
Background To investigate the relationship between obesity and corneal nerve metrics in patients with type 2 diabetes mellitus (DM). Methods This cross-sectional study included a total of 385 healthy controls and 663 patients with DM. Metrics for corneal
Calesta Hui Yi Teo, Chang Liu, Mingyi Yu, Isabelle Xin Yu Lee, Ansa Anam, Ching-Yu Cheng, Yadana Htunwai, Jasmine Shimin Koh, Suresh Rama Chandran, Yu-Chi Liu   +9 more
doaj   +1 more source

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

Advanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song, Yifan Wang, Lili Wang, Chang Guo, Shiqi Liu, Yi Rong, Jiawen Tian, Chao Peng, Yuying Shao, Zhixiong Ma, Na Li, Jingliang Zhang, Zijun Peng, Xu Yan, Hangwei Fa, Xinyue Ma, Jie Dong, Jinping Ji, Chen Yang, Haocheng Chen, Jing Liang, Qi Sun, Yang Yang, Weining Ma, Zhuo Huang   +24 more
wiley   +1 more source

Refractive surgery beyond 2020

Eye, 2020
M. Ang, D. Gatinel, D. Reinstein, E. Mertens, J. L. Alio del Barrio, J. Alió   +5 more
semanticscholar   +1 more source

Advanced Microfluidics for Single Cell‐Based Cancer Research

Advanced Science, EarlyView.
Cutting‐edge microfluidic platforms are transforming single‐cell cancer research. This review highlights advanced technologies, from droplet microfluidics to tumour‐chips, that enable functional and spatial single‐cell analyses. By integrating biosensing, immune components, and patient‐derived materials, these systems offer new insights into tumour ...
Adriana Carneiro, Marta Aranda Palomer, Margarida Esteves, Carolina Rodrigues, José Maria Fernandes, Francisca Oliveira, Alexandra Teixeira, Carlos Honrado, Lorena Dieguez, Sara Abalde‐Cela, Miguel Xavier   +10 more
wiley   +1 more source

Inflammatory Response in the Anterior Chamber after Implantation of an Angle-Supported Lens in Phakic Myopic Eyes

Journal of Ophthalmology, 2014
Purpose. To evaluate the inflammatory reaction after implantation of an angle-supported foldable acrylic anterior chamber IOL for myopia correction over time. Methods.
Suphi Taneri, Saskia Oehler, Carsten Heinz   +2 more
doaj   +1 more source

Keratocyte apoptosis and corneal antioxidant enzyme activities after refractive corneal surgery [PDF]

, 2002
Kamil Bïlgïhan, Ayşe Bılgıhan, Ufuk Adıgüzel, Cem Sezer, Özgür Mehmet Yis, Gülen Akyol, Berati Hasanreisoğlu   +6 more
openalex   +1 more source

Complications of Refractive Surgery [PDF]

International Ophthalmology Clinics, 2016
Meraf A. Wolle, J. Bradley Randleman, Maria A. Woodward   +2 more
openaire   +3 more sources

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Advanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie, Meng Pan, Zeyuan Zhang, Licheng Zhang, Haotian Liu, Xia Wang, William W Lu, Peifu Tang, Wei Ge   +8 more
wiley   +1 more source