Results 231 to 240 of about 6,842 (303)

Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors

Advanced Science, EarlyView.
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng, Peipei Wang, Pengfei Wang, Jiamin Wang, Baiyang Li, Daqing Fang, Jian He, Xiaobei Hu, Weijuan Kan, Yubo Zhou, Chunpu Li, Jia Li, Hong Liu   +12 more
wiley   +1 more source

The influence of the ratio between Li₂O and B₂O₃ on optical, luminescence, and thermal properties of samarium-doped lithium borate glass. [PDF]

Sci Rep
Kashif I, Ratep A.
europepmc   +1 more source

Laser‐Induced Periodic Phase‐Transition of 2D‐MoTe2 Nanograting Template for Frequency‐Shift Digital‐SERS Immunoassay of Autoimmune Disease

Advanced Science, EarlyView.
A protocol of fs‐laser‐induced periodic phase‐transition of 2D‐MoTe2 template, inducing AuNPs@1T’‐MoTe2 nanograting, is developed. The labeled AuNPs@1T’‐MoTe2 substrate conjugated with specialized immunoglobulin G demonstrates an unexpectedly high discrimination accuracy close to unity for serological diagnosis of rheumatoid arthritis by frequency ...
Yao Yao, Lulu Cao, Xiaolin Sun, Qiang Wang, Zhiyang Xu, Tianrui Zhai, Yan Zhao, Yijian Jiang, Zhanguo Li, Yinzhou Yan   +9 more
wiley   +1 more source

A paradigmatic approach to the topological measure of babesiosis drugs and estimating physical properties via QSPR analysis.

Heliyon
Awan NUH, Ghani MU, Bibi S, Kirmani SAK, Abdalla MEM.   +4 more
europepmc   +1 more source

Resolving the boron anomaly in SrF₂-borate glasses using combined MRN-TCT-percolation framework. [PDF]

Sci Rep
El-Raouf EA, Hamalawy A, Hassan S.
europepmc   +1 more source

A Dual‐Channel Synergistic Ultrasensitive Biosensor for Tumor Liquid Biopsy

Advanced Science, EarlyView.
ABSTRACT Liquid biopsy technology, which detects circulating tumor DNA (ctDNA) in cerebrospinal fluid, plays a crucial role in the early diagnosis and precision treatment of gliomas. However, the intrinsically low abundance and rapid clearance of ctDNA pose substantial challenges for conventional analytical techniques, such as droplet digital PCR and ...
Yu Sun, Jing Zhang, Chenqing Liu, Jing Lou, Sihui Wang, Xiangtian Ji, Xiaofang Zhao, Shirui Xu, Jingyu Feng, Bin Liu, Chao Chang, Qinggang Ge, Jun Yang   +12 more
wiley   +1 more source

Computational approaches in drug chemistry leveraging python powered QSPR study of antimalaria compounds by using artificial neural networks. [PDF]

Sci Rep
Ahmed W, Ashraf T, Saleem MT, Mahmoud EE, Ali K, Zaman S, Belay MB.   +6 more
europepmc   +1 more source

Ultra‐Low Intensity Continuous Wave Laser Ablation Propulsion With Graphene‐Engineered Wood

Advanced Science, EarlyView.
Graphene delignified wood converts continuous wave laser energy into thrust. Laser propulsion experiments in vacuum reveal the lowest laser ablation threshold intensities and the greatest density‐normalized specific impulse in literature. The results highlight graphene delignified wood as a potential efficient, sustainable, strong, and lightweight ...
Afnan S. M. Elmubasher, Rami Elkaffas, Mohamed Hamid Salim, Basel Altawil, Chanaka Sandaruwan, Shanavas Shajahan, Ahsan Baidar Bakht, Irfan Hussain, Blaise L. Tardy, Sean S. M. Swei, Yarjan Abdul Samad   +10 more
wiley   +1 more source

Tailoring optical nonlinearity and gamma-ray shielding in [Formula: see text]-modified borate-BCZT glasses. [PDF]

Sci Rep
Gaber EA, Hussien SA, Saad EM, Hassan MA.   +3 more
europepmc   +1 more source

Multiscale Architecture and Mechanics of the Cell Nucleus: Implications for Disease, Bioengineering and Nanomedicine

Advanced Science, EarlyView.
Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu, Xin Chen, Qingyang Zhao, Weikang Tan, Lingrui Zhu, Kin Liao, Vincent Chan, Nicolae Goga, Winfred O. Larkotey, Yang Li, Yinghui Shi, Wenya Shu, Lin Wang, Weiqing Wang, Tian Jian Lu, Yulong Han   +15 more
wiley   +1 more source