Results 161 to 170 of about 585,126 (313)

Surgical cystotomy for refractory diabetic cystoid macular edema

, 2018
Koushik Tripathy Department of Vitreoretina and Uvea, ICARE Eye Hospital & Postgraduate Institute, Noida, IndiaI read with interest the article on cystotomy for refractory diabetic cystoid macular edema (CME) by Asahina et al.1 Intraoperative ...
Tripathy K
core  

Incidence and Outcomes of Refractory Septic Shock per Consensus Clinical Criteria: A Multicohort Retrospective Study. [PDF]

Crit Care Med
Bauer SR, Wieruszewski PM, Khanna AK, Leone M, Barreto EF, Dugar S, Sacha GL, Mourany L, Gunsalus PR, Milinovich A, Reddy AJ, Kane-Gill SL, Tarabichi Y, Wang X, Dalton JE, Vachharajani V.   +15 more
europepmc   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Treatment of the refractory angina in the very elderly patients and centenarians

, 2016
In clinical practice, elderly patients are often refractory to the treatment of stable angina, including after revascularization. Clinical case is shown which illustrates problems and possibilities of refractory angina treatment in the elderly patients ...
Yu.A. Borkhalenko, O.P. Nadorak, S.I. Mashkovska, O.A. Yepanchintseva, O.J. Zharinov   +4 more
core  

Interface Behavior and Corrosion Study of MgO-Based Refractory Materials in Molten Pharmaceutical Waste Salts. [PDF]

Materials (Basel)
Yang Q, He F, Cheng W, Gao M, Xie J.
europepmc   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Evaluation of Refractory Autoimmune Hemolytic Anemia Patients After Splenectomy

Objective: In this study, we aimed to retrospectively evaluate the results of patients with autoimmune hemolytic anemia (AIHA) who had undergone splenectomy.
Mehmet Günhan Tekin, Memiş Hilmi Atay
core   +1 more source

Effectiveness of the P2X₃ Antagonist Gefapixant for Refractory Atopic Cough: A Retrospective Cohort Study. [PDF]

J Asthma Allergy
Ishiura Y, Nomura S, Ohkura N, Hara J, Fujimura M, Ito T.   +5 more
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Refractory nail lichen planus treated successfully with the Janus kinase 1 inhibitor abrocitinib: A case report. [PDF]

J Int Med Res
Wang L, Lei X, Li L, Cheng Q.
europepmc   +1 more source