Results 221 to 230 of about 906,079 (292)

Deformable Eutectic Alloy With Near‐Theoretical Yield Strength via Hierarchical Nanoscale Multiphases and Sessile Defects

Advanced Science, EarlyView.
A CoCrFeNiTa0.4 eutectic high‐entropy alloy achieves a near‐theoretical yield strength of 2.6 GPa with 13.6% plasticity. This breakthrough stems from a hierarchical nanostructure (FCC‐Laves lamellae with L12/D022 precipitates), which alleviates the inter‐phase modulus/hardness mismatch through synergistic strengthening and toughening, guiding the ...
Yusha Luo, Qianqian Wang, Bo Sun, Ruixin Sheng, Zhijun Guo, Gaopeng Zou, Zhe Jia, Yang Tong, Gang Sha, Peter K. Liaw, Baolong Shen   +10 more
wiley   +1 more source

Ganglion Impar Neurolysis With 60% Alcohol for Refractory Post-Traumatic Coccygodynia: A Case Report With Sustained Relief. [PDF]

Clin Case Rep
Kumar P, Dahal A, Ghimire S, Bhatta R.
europepmc   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Management of duodenal foreign bodies using the novel combined laparoscopic and endoscopic approaches in two unique cases

Asian Journal of Surgery
Fang-Tao Wang, Ren-Yuan Gao, Tian-Qi Wu, Chun-Qiu Chen   +3 more
doaj   +1 more source

Possible Involvement of Skin-Resident Memory T Cells in Refractory Chronic Alopecia Areata. [PDF]

Exp Dermatol
Kageyama R, Ito T, Kurihara K, Fujiyama T, Honda T.   +4 more
europepmc   +1 more source

Targeting PRKCN, an Essential Driver Orchestrating mTOR‐IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma

Advanced Science, EarlyView.
Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang, Dongpeng Jiang, Peng Ke, Xiaosen Bian, Lili Zhang, Ying Zhang, Tingting Zhu, Weiwei Qu, Wenhui Qi, Yang Xu, Chengcheng Fu, Depei Wu, Jianhong Chu   +12 more
wiley   +1 more source

Claustrum Sign: An Increasingly Recognized Imaging Feature of New-Onset Refractory Status Epilepticus (NORSE). [PDF]

Neurohospitalist
Abdullah M, Chen T.
europepmc   +1 more source

CsdA‐LaeB Regulatory Hub Contributes to Aspergillus fumigatus Virulence via Fumiquinazoline C Biosynthesis

Advanced Science, EarlyView.
This study identifies a conserved CsdA‐LaeB hub in Aspergillus fumigatus that regulates secondary metabolite fumiquinazoline C (FqC). Disrupting this hub enhances FqC production and virulence, shedding new light on the post‐transcriptional regulatory logic linking secondary metabolism to pathogenicity and offering alternative strategies for diagnostic ...
Zili Song, Hongjiao Zhang, Leixin Ye, Yuxin Lei, Linqi Wang, Xiao Liu, Nayanna M. Mercado Soto, Nancy P. Keller, Berl R. Oakley, Can Zhao, Michael Bromley, Hongwei Liu, Lei Cai, Koon Ho Wong, Wen‐Bing Yin   +14 more
wiley   +1 more source

Aluminum Spent Foundry Sand as an Emergent Raw Material in the Production of a Sustainable Aluminosilicate Refractory Castable. [PDF]

Materials (Basel)
López-Perales JF, Díaz-Tato L, González-Carranza Y, Contreras de León JE, Gómez-Rodríguez C, Fernández-González D, Rodríguez-Castellanos EA.   +6 more
europepmc   +1 more source