Results 221 to 230 of about 911,530 (311)

Clinical and OCT Predictors of Refractory Vogt-Koyanagi-Harada Disease. [PDF]

Ophthalmol Sci
Cho YC, Mizuki Y, Nakamura J, Meguro A, Kanasashi S, Sakono T, Kawagoe T, Ohno S, Mizuki N.   +8 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Case Report: Successful treatment of steroid-refractory severe immunotherapy-induced pneumonitis with equine antithymocyte globulin. [PDF]

Front Oncol
Luong TTV, Lin L, Coutsouvelis J, Dabscheck E, Ivulich S, Burridge H, Keating D, Shackleton M, Haydon A, Andrews MC.   +9 more
europepmc   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

A Child With Iron-Refractory Iron Deficiency Anemia: A Rare Case Associated With Hiatal Hernia. [PDF]

Clin Case Rep
Ketema W, Garie KT, Mame ET, Shifeta M, Gizaw W, Hamid S, Kassim Ahmed R, Yasin T, Leykun SK, Dejene A, Hirigo AT, Shibeshi MS.   +11 more
europepmc   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Refractory oral and cutaneous lichen planus successfully treated with upadacitinib. [PDF]

JAAD Case Rep
Riekhof I, Reed A, Pham A.
europepmc   +1 more source

Structural Eigenmodes of the Brain to Improve the Source Localization of EEG: Application to Epileptiform Activity

Advanced Science, EarlyView.
Geometry and connectivity are complementary structures, which have demonstrated their ability to represent the brain's functional activity. This study evaluates geometric and connectome eigenmodes as biologically informed constraints for EEG source localization.
Pok Him Siu, Philippa J. Karoly, Sina Mansour L., Artemio Soto‐Breceda, Levin Kuhlmann, Mark J. Cook, David B. Grayden   +6 more
wiley   +1 more source

Duodenal metastasis from breast carcinoma presenting with refractory nausea and vomiting: a case report. [PDF]

J Surg Case Rep
Shannon Naing SS.
europepmc   +1 more source