Results 251 to 260 of about 585,126 (313)

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

Device-Specific Responses to Pacemaker-Mediated Arrhythmia in Patients With Prolonged Ventriculoatrial Conduction: A Comparative Simulation Study. [PDF]

J Arrhythm
Tsunomori M, Imamura T, Nagamine D, Okino S, Iio H, Sato K, Kataoka N, Uchida K, Kinugawa K.   +8 more
europepmc   +1 more source

BCMA‐Engineered Dendritic Cell‐Derived Exosomes as Bi‐Functional Therapeutics Orchestrating Cytokine Sequestration and Immune Activation for Multiple Myeloma

Advanced Science, EarlyView.
A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng, Chao He, Zhibin He, Hongbo Chen, Fang Cheng, Yongjiang Zheng   +5 more
wiley   +1 more source

Study on the Synergistic Enhancement of Mechanical Properties of Magnesia-Chrome Refractory Bricks Through Component Ratio Optimization and Salt Impregnation Process. [PDF]

Materials (Basel)
Zou L, Qi Y, Cheng B, Wang W, Guo K.
europepmc   +1 more source

Neuromorphic Near‐Sensor and In‐Sensor Computing Enabled by Next‐Generation Material‐Based Sensors

Advanced Science, EarlyView.
This Review presents a structural framework that classifies neuromorphic sensing into near‐sensor and in‐sensor architectures, clarifying physical coupling between sensing and computation. The framework connects neural and synaptic device functions with recent advances in optical, mechanical, and chemical sensing, compares energy consumption and ...
Su Yeon Jung, Gwang Ya Kim, Sejin Kim, Hyunjong Seo, Se Gi Lee, Sang Min Won, Dongjoon Rhee, Joohoon Kang   +7 more
wiley   +1 more source

Refractory chylothorax caused by massive thymic hyperplasia in an infant: thoracoscopic thymectomy. [PDF]

Int J Surg Case Rep
Ban HT, Tran HV, Huynh QTV, Le PS, Lai HL, Nguyen PH.   +5 more
europepmc   +1 more source

Targeting Neuroinflammation and Peripheral Nerve Dysfunction in Refractory Postherpetic Neuralgia: A Multimodal Injection Case Series. [PDF]

Am J Case Rep
Janitra G, Susila D, Liem L.
europepmc   +1 more source

Refractory Periungual Warts Treated with Filiform Fire Needle Combined with Warming-Yang and Collateral-Dredging Chinese Medicine Soak: A Two-Case Report. [PDF]

Clin Cosmet Investig Dermatol
Lyu S, Chong Z, Yu T, Ruan C.
europepmc   +1 more source

Cranioplasty as a therapeutic intervention for refractory postdecompressive craniectomy seizures in combat-traumatic brain injury: A report of two cases. [PDF]

Surg Neurol Int
Ndandja DTK, Kim AV, Antonov GI, Musa G, Chmutin GE, Abrosimov SS, Taukanov IA, Martynov AY.   +7 more
europepmc   +1 more source