Results 161 to 170 of about 991 (250)

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Enhancing the Elevated-Temperature Mechanical Properties of Levitation Melted NbMoTaW Refractory High-Entropy Alloys via Si Addition. [PDF]

Materials (Basel)
Liu Y, Li X, Lu S, Zhou J, Wu S, Lin S, Wang L.   +6 more
europepmc   +1 more source

Simultaneous strength and ductility improvement of As-cast HfMoTaTiZrCr _<i>x</i> refractory high entropy alloys <i>via</i> Cr addition. [PDF]

RSC Adv
Xu M, Bai L, Guo X, Wang H, Lee K, Geng Z, Wang J.   +6 more
europepmc   +1 more source

Mystery and misery of locally‐delivered drug therapy in periodontics. Historical concepts and current state

Periodontology 2000, EarlyView.
Abstract The primary objective is to critically analyze approaches to local therapy for periodontal disease, particularly in light of its well‐established systemic implications. We specifically address common misconceptions and overestimations regarding the potential of local treatments in contrast to their actual clinical effectiveness.
Andrea Mombelli, Alkisti Zekeridou
wiley   +1 more source

Anomalous component-dependent lattice thermal conductivity in MoWTaTiZr refractory high-entropy alloys. [PDF]

iScience
Zhang J, Zhang H, Xiong J, Chen S, Zhang YW, Zhang G.   +5 more
europepmc   +1 more source

Role of BK Virus CTLs in the Treatment of BK Virus–Associated Nephropathy in Kidney‐Transplant and Hematopoietic Cell Transplant Recipients

Transplant Infectious Disease, EarlyView.
Third‐party, BK virus‐specific cytotoxic T lymphocytes (CTLs) were safe and effective in reducing viremia in kidney and stem cell transplant recipients with BK virus nephropathy. However, they did not improve kidney function. Earlier administration may be more beneficial before nephropathy and irreversible damage occur.
Amanda Olson, Ye Ethan Li, Rafet Basar, Pinaki Banerjee, Indresh Kaur, Glorette Abueg, Melihate Sylejmani, Nadima Uprety, Rejeena Shrestha, Francia Reyes Silva, Valda Page, Richard E. Champlin, Dimitrios P. Kontoyiannis, Roy F. Chemaly, Elizabeth J. Shpall, Linda Moore, Osama A. Gaber, Katayoun Rezvani, Ala Abudayyeh   +18 more
wiley   +1 more source

Multi-Phase Design Strategy for Synergistic Strength-Ductility Optimization in V-Ti-Cr-Nb-Mo Refractory High-Entropy Alloys. [PDF]

Materials (Basel)
Liang X, Zhu J, Tan Z, Chen R, Chen Y, Tao X.   +5 more
europepmc   +1 more source

Predicting Learning: Understanding the Role of Executive Functions in Children's Belief Revision Using Bayesian Models

Topics in Cognitive Science, EarlyView.
Abstract Recent studies suggest that learners who are asked to predict the outcome of an event learn more than learners who are asked to evaluate it retrospectively or not at all. One possible explanation for this “prediction boost” is that it helps learners engage metacognitive reasoning skills that may not be spontaneously leveraged, especially for ...
Joseph A. Colantonio, Igor Bascandziev, Maria Theobald, Garvin Brod, Elizabeth Bonawitz   +4 more
wiley   +1 more source

Nonequilibrium phase diagram for the serration statistics during slow deformation of refractory high-entropy alloys. [PDF]

Sci Rep
Liu MW, Hsu WC, Chiang TY, Tsai CW, Dahmen KA.   +4 more
europepmc   +1 more source

Endoscopic management of acute cholecystitis in high‐risk surgical patients: A comprehensive review article

DEN Open, Volume 6, Issue 1, April 2026.
Abstract Acute cholecystitis is frequently encountered in daily clinical practice, and early cholecystectomy is the standard therapy. In high‐risk surgical patients, such as those with advanced age, deteriorated performance status, or underlying diseases, conservative treatment is typically preferred to manage acute cholecystitis.
Akinori Maruta, Takuji Iwashita, Kensaku Yoshida, Shogo Shimizu, Masahito Shimizu   +4 more
wiley   +1 more source