Results 181 to 190 of about 59,639 (336)

Development of a preclinical testing platform for clinically relevant therapy for Dravet syndrome

Epilepsia, EarlyView.
Abstract Objective Patients with drug‐resistant epilepsy, including Dravet syndrome, are frequently prescribed multiple antiseizure medications. Nevertheless, people with Dravet syndrome often have inadequate seizure control, and there is an ongoing unmet clinical need to identify novel therapeutics.
Jeffrey A. Mensah, Kyle E. Thomson, Jennifer L. Huff, Tia Freeman, Christopher A. Reilly, Joseph E. Rower, Cameron S. Metcalf, Karen S. Wilcox   +7 more
wiley   +1 more source

P2X7 receptor in epilepsy; role in pathophysiology and potential targeting for seizure control. [PDF]

, 2012
The P2X7 receptor is an ATP-gated non-selective cation-permeable ionotropic receptor selectively expressed in neurons and glia in the brain. Activation of the P2X7 receptor has been found to modulate neuronal excitability in the hippocampus and it has ...
Diaz-Hernandez, Miguel, Engel, Tobias, Henshall, David C, Jimenez-Pacheco, Alba, Miras-Portugal, Maria Teresa   +4 more
core   +2 more sources

Optimizing phenobarbital dosing in critically ill patients with refractory and superrefractory status epilepticus using a population pharmacokinetic model

Epilepsia, EarlyView.
Abstract Objective Current weight‐based dosing fails to account for pharmacokinetic variability in refractory and superrefractory status epilepticus (RSE, SRSE). However, understanding pharmacokinetics in critically ill patients with varying degrees of organ dysfunction can improve both safety and efficacy.
Maximilian Stoschus, Moritz L. Schmidbauer, Johannes Starp, Stefan Kunst, Georgios Gakis, Michael Paal, Michael Vogeser, Christina Scharf‐Janssen, Uwe Liebchen, Konstantinos Dimitriadis   +9 more
wiley   +1 more source

Estado epiléptico no convulsivo en el siglo XXI: clínica, diagnóstico, tratamiento y pronóstico [PDF]

, 2012
Non-convulsive status epilepticus is a significant issue for a neurologist because, despite its low prevalence, it mimics other pathologies, with therapeutics and prognostic outcomes.
Gomez-Ibañez, A. (Asier), Urrestarazu, E. (Elena), Viteri, C. (César)   +2 more
core  

Refractory status epilepticus: A prospective observational study [PDF]

, 2009
Jan Nový, Giancarlo Logroscino, Andrea O. Rossetti   +2 more
openalex   +1 more source

Tumor‐related epilepsy in glioma: A multidisciplinary overview

Epilepsia, EarlyView.
Abstract Seizures are a common and challenging symptom in brain tumors, affecting approximately 60% of patients. Tumor‐related epilepsy (TRE) in glioma patients requires personalized and dynamic management in a multidisciplinary environment, especially for its intricate pathophysiology and unpredictable disease evolution. This investigation provides an
Roberto Michelucci, Giada Pauletto, Antonio Silvani, Elena Pasini, Tamara Ius, Matteo Martinoni, Carlo Alberto Castioni, Andrea Salmaggi, Sofia Asioli, Marta Maschio, Giuseppe Minniti, Enrico Franceschi, Flavio Villani, Roberta Rudà, Eleonora Aronica, the Italian Multidisciplinary Group for Tumor Epilepsy, Paolo Vitali, Damiano Balestrini, Elisa D’Angelo, Lorenzo Bello, Marco Rossi, Marta Padovan, Anna Teresa Giallonardo, Carlo di Bonaventura, Francesco Toni, Angela La Neve, Simona Rizzato, Matteo Pugnaghi, Marco Vindigni, Carmelo Sturiale   +29 more
wiley   +1 more source

The impact of revised definitions on the epidemiology of status epilepticus: A population‐based study

Epilepsia, EarlyView.
Abstract Objective Status epilepticus (SE) represents one of the most common neurological emergencies. The International League Against Epilepsy (ILAE) redefined SE duration thresholds from 30 to 5 min for convulsive SE in 2015. We conducted a prospective population‐based study to determine SE incidence and outcomes under the revised criteria and ...
Meike Menche, Clara Jünemann, Jens‐Peter Reese, Martin Jünemann, Michael Teepker, Christoph Best, Christian Roth, Ingrid Sünkeler, Elisabeth Pryss, Felix Rosenow, Adam Strzelczyk, Leona Möller, Lena Habermehl, Panagiota‐Eleni Tsalouchidou, Ole Simon, Andre Kemmling, Christopher Nimsky, Lars Timmermann, Katja Menzler, Susanne Knake   +19 more
wiley   +1 more source

Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof‐of‐concept clinical study

Epilepsia, EarlyView.
Abstract Objective Drug‐resistant epilepsy (DRE) affects >25 million people worldwide and is often associated with neuroinflammation. Increasing evidence links deficiency or malfunctioning of the enzyme phosphoglycerate dehydrogenase (PHGDH), which converts 3‐phosphoglycerate to generate serine and the neurotransmitter glycine, with (drug‐resistant ...
Karin Thevissen, Annelii Ny, Daniëlle Copmans, Jana Tits, Kenichi Kamata, Eva Gielis, Kevin Longin, Jo Sourbron, Peravina Thergarajan, Tracie Huey‐Lin Tan, Idrish Ali, Nigel C. Jones, Terence J. O'Brien, Mastura Monif, Bridgette D. Semple, Christine Germeys, Benedetta Frizzi, Virginia Minniti, Sebastian Perrone, Carole L. Linster, Ilaria Elia, Ludo Van Den Bosch, Bruno P. A. Cammue, Arnout Voet, Lieven Lagae, Peter de Witte   +25 more
wiley   +1 more source

A Randomized Trial for the Treatment of Refractory Status Epilepticus [PDF]

, 2010
Andrea O. Rossetti, Tracey Milligan, Serge Vulliémoz, Costas Michaelides, Manuel Bertschi, Jong Woo Lee   +5 more
openalex   +1 more source

De novo pathogenic CSF1R variant implicates microglial dysfunction in pathogenesis of febrile infection‐related epilepsy syndrome

Epilepsia, EarlyView.
Abstract Febrile infection‐related epilepsy syndrome (FIRES) is a rare presentation of refractory status epilepticus following a febrile illness with resulting refractory epilepsy. Evidence supports the presence of immune dysregulation in patients with FIRES, but a monogenic basis for FIRES has not been identified in most cases.
Kristen S. Fisher, Jesse M. Levine, Alexander Ankar, Ruizhi Duan, Yi Chen Lai, Eyal Muscal, Sarah R. Risen, James J. Riviello, Pei‐Chien Tsai, Daniel G. Calame   +9 more
wiley   +1 more source