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Treatment of Refractory Status Epilepticus in Childhood
Current Neurology and Neuroscience Reports, 2010Refractory status epilepticus (RSE) is characterized by a prolonged seizure that persists despite adequate initial management. RSE accounts for almost one quarter of all status epilepticus and carries significant risk for morbidity and mortality. Treatment varies widely between institutions regarding medication choice, dose, and monitoring.
William D. Gaillard, John M. Schreiber
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The role of PCDH19 in refractory status epilepticus
Epilepsy & Behavior, 2019PCDH19-Girls Clustering Epilepsy (GCE) is an epileptic syndrome with infantile onset, characterized by clustered and fever-induced seizures, often associated with intellectual disability (ID) and autistic features. Seizures clusters could progress into status epilepticus (SE) with different semiology, both convulsive and nonconvulsive SE (NCSE), and ...
Nicola Specchio, Marina Trivisano
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Midazolam and pentobarbital for refractory status epilepticus
Pediatric Neurology, 1999Status epilepticus, a serious, life-threatening emergency characterized by prolonged seizure activity, occurs most commonly in pediatric patients. Although initial therapies with agents such as diazepam, phenytoin, or phenobarbital generally terminate seizure activity within 30-60 minutes, patients with refractory status epilepticus (RSE) lasting ...
James J. Riviello, Gregory L. Holmes
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New Developments in Refractory Status Epilepticus
Neurologic Clinics, 2017Status epilepticus (SE) is a medical emergency and presents with either a continuous prolonged seizure or multiple seizures without full recovery of consciousness in between them. The goals of treatment are prompt recognition, early seizure termination, and simultaneous evaluation for any potentially treatable cause.
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Pentobarbital treatment of refractory status epilepticus
Neurology, 1987We studied nine patients with status epilepticus refractory to standard therapy. In all patients so treated, IV pentobarbital terminated seizure activity. Mortality was high (77%) in those treated, but was attributed to underlying pathology and possibly to duration of status epilepticus.
Mitchell C. Rashkin +2 more
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Lacosamide for the Treatment of Refractory Status Epilepticus
Annals of Pharmacotherapy, 2011Objective:To evaluate current evidence for the use of lacosamide in the treatment of refractory status epilepticus.Data Sources:Literature was accessed via PubMed (through July 2011) using the terms lacosamide and status epilepticus.Study Selection and Data Extraction:All reports on the use of lacosamide in patients with status epilepticus were ...
Andrew J. Franck, Erica M Fernandez
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Neuropathology of New-Onset Refractory Status Epilepticus (NORSE)
Journal of Neurology, 2023A. Hanin +8 more
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Electroencephalographic Reporting for Refractory Status Epilepticus
Journal of Clinical Neurophysiology, 2019Purpose: We aimed to determine whether clinical EEG reports obtained from children in the intensive care unit with refractory status epilepticus could provide data for comparative effectiveness research studies. Methods: We conducted a retrospective descriptive study to assess the ...
Joshua L. Goldstein +27 more
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Pathogenesis of Refractory Status Epilepticus
2017The most significant characteristic of seizures is self-limitation, which is associated with the postictal refractory period that follows a seizure. The endogenous anticonvulsant mechanism is one of the most important reasons that seizures self-terminate.
Zhifang Dong, Zhong Chen
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