Results 171 to 180 of about 1,641,482 (341)

Tunable Synthetic Hydrogel Modulates Hepatic Lineage Specification of Human Liver Organoid

Advanced Functional Materials, EarlyView.
In this study, a synthetic hydrogel is reported that supports the formation of hiPSC‐derived human liver organoids (HLOs). Hepatic lineage specification can be modulated via conjugation of RGD peptide to hydrogel: RGD‐conjugated hydrogels promote cholangiocyte differentiation, whereas RGD‐free hydrogels favor hepatocyte commitment of HLO cells.
Lei Wang, Lasse Riediger, Qi Rao, Xun Xu, Yan Nie, Yiduo Zhou, Junyao Zhang, Peng Tang, Weiwei Wang, Frank Tacke, Adrien Guillot, Ludovic Vallier, Irene Talon, Wenzhong Li, Yi‐An Yang, Rainer Haag, Nan Ma   +16 more
wiley   +1 more source

Calcium Imparts Advanced Functionalities to Silk Hydrogels for Biofabrication and Biomedical Innovation

Advanced Functional Materials, EarlyView.
The addition of calcium ions to silk fibroin enhances the hydrogel properties and, when combined with visible light crosslinking, enables compatibility with advanced light‐based fabrication techniques. Calcium ions extend the shelf‐life of silk and facilitate the fabrication of multizonal, multilayered constructs for advanced stimuli‐responsive ...
Hien A. Tran, Anton Maraldo, Chi Cong Nguyen, Trinh Thi‐Phuong Ho, Lauryn Srethbhakdi, Habib Joukhdar, Quinn van Hilst, Syamak Farajikhah, Fariba Dehghani, Thanh Nho Do, Khoon S. Lim, Jelena Rnjak‐Kovacina   +11 more
wiley   +1 more source

Intracellular Regeneration of Glucocorticoids by11β-Hydroxysteroid Dehydrogenase (11β-HSD)-1 Plays a KeyRole in Regulation of the Hypothalamic-Pituitary-Adrenal Axis: Analysisof 11β-HSD-1-Deficient Mice**The Wellcome Trust supported this work through a program grant (to J.J.M. and J.R.S.) and a Career Development Fellowship (to M.C.H.). [PDF]

, 2001
Hayley J. Harris, Yuri Kotelevtsev, John J. Mullins, Jonathan R. Seckl, Megan C. Holmes   +4 more
openalex   +1 more source

The rationale behind implant coatings to promote osteointegration, bone healing or regeneration [PDF]

, 2020
Kai Borcherding, Gerhard Schmidmaier, Gunther O. Hofmann, Britt Wildemann   +3 more
openalex   +1 more source

Synergistic Osteogenesis After Co‐Administration of cmRNAs Encoding BMP‐2 and BMP‐7 Utilizing a Transcript‐Activated Matrix

Advanced Functional Materials, EarlyView.
This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...
Claudia Del Toro Runzer, Joanna M. Sadowska, Nadia Roumans, Christian Plank, Christopher H. Evans, Fergal J. O'Brien, Martijn van Griensven, Elizabeth R. Balmayor   +7 more
wiley   +1 more source

Hepatocytes differentiate into intestinal epithelial cells through a hybrid epithelial/mesenchymal cell state in culture

Nature Communications
Hepatocytes play important roles in the liver, but in culture, they immediately lose function and dedifferentiate into progenitor-like cells. Although this unique feature is well-known, the dynamics and mechanisms of hepatocyte dedifferentiation and the ...
Shizuka Miura, Kenichi Horisawa, Tokuko Iwamori, Satoshi Tsujino, Kazuya Inoue, Satsuki Karasawa, Junpei Yamamoto, Yasuyuki Ohkawa, Sayaka Sekiya, Atsushi Suzuki   +9 more
doaj   +1 more source

Nanoparticles of cobalt-substituted hydroxyapatite in regeneration of mandibular osteoporotic bones [PDF]

, 2012
Nenad Ignjatović, Zorica Ajduković, Vojin Savić, Stevo Najman, D. Mihailović, Perica Vasiljević, Zoran Stojanović, Vuk Uskoković, Dragan Uskoković   +8 more
openalex   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Decellularized Human Dental Pulp as a Scaffold for Regenerative Endodontics

, 2017
Je Seon Song, Koyo Takimoto, Myung Jae Jeon, J Vadakekalam, Nikita B. Ruparel, Aníbal Diogenes   +5 more
openalex   +2 more sources

New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination [PDF]

, 2020
Sarah A. Neely, J Williamson, Anna Klingseisen, Lida Zoupi, Jason J. Early, Anna Williams, David A. Lyons   +6 more
openalex   +1 more source