Results 91 to 100 of about 1,651,358 (339)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Neuroinflammation as Fuel for Axonal Regeneration in the Injured Vertebrate Central Nervous System
Mediators of Inflammation, 2017 Damage to the central nervous system (CNS) is one of the leading causes of morbidity and mortality in elderly, as repair after lesions or neurodegenerative disease usually fails because of the limited capacity of CNS regeneration.
Ilse Bollaerts +4 more
doaj +1 more source
Cell Reports, 2014 Thymic epithelial cells (TECs) are critical for T cell development and self-tolerance but are gradually lost with age. The existence of thymic epithelial progenitors (TEPCs) in the postnatal thymus has been inferred, but their identity has remained ...
Kahlia Wong +9 more
doaj +1 more source
Review Article: Is Wnt Signaling an Attractive Target for the Treatment of Osteoarthritis?
Rheumatology and Therapy, 2020 Osteoarthritis is the most common chronic joint disease affecting millions of people worldwide and a leading cause of pain and disability. Increasing incidence of obesity and aging of the population are two factors that suggest that the impact of ...
Rik J. Lories, Silvia Monteagudo
doaj +1 more source
Bone Regeneration and Repair: Biology and Clinical Applications [PDF]
The Annals of The Royal College of Surgeons of England, 2006 The editors of this book have aimed to provide the currently available information regarding the biology of bone formation and repair to review the basic science of autologous bone graft, skeletal allograft, bone graft substitutes and growth factors and to explore the clinical applications of these technologies. They have brought together the expertise
openaire +2 more sources
Current trends in single‐cell RNA sequencing applications in diabetes mellitus
FEBS Open Bio, EarlyView.Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian +6 more
wiley +1 more source
Regeneration of injured skeletal muscle after the injury.
Muscles Ligaments and Tendons Journal, 2019 Muscle injuries are one of the most common traumas occurring in sports. Despite their clinical importance, few clinical studies exist on the treatment of these traumas.
T. Järvinen, M. Järvinen, H. Kalimo
semanticscholar +1 more source
FEBS Open Bio, EarlyView.We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado +4 more
wiley +1 more source
Nature Cell Biology, 2019 Tendon injuries cause prolonged disability and never recover completely. Current mechanistic understanding of tendon regeneration is limited. Here, we use single-cell transcriptomics to identify a tubulin polymerization-promoting protein family member 3 ...
T. Harvey, Sara Flamenco, C. Fan
semanticscholar +1 more source
Report on the 2nd MObility for Vesicle research in Europe (MOVE) symposium—2024
FEBS Open Bio, EarlyView.The 2nd MObility for Vesicle research in Europe (MOVE) Symposium in Belgrade brought over 280 attendees from 28 countries to advance extracellular vesicle (EV) research. Featuring keynotes, presentations, and industry sessions, it covered EV biogenesis, biomarkers, therapies, and manufacturing.
Dorival Mendes Rodrigues‐Junior +5 more
wiley +1 more source