Results 91 to 100 of about 1,870,035 (300)

Myocardial Regeneration for Humans　― Modifying Biology and Manipulating Evolution ―

Circulation Journal, 2017
Cardiovascular disease remains the leading cause of death worldwide and developing novel therapies to treat and cure the disease remains a high priority in the healthcare research community. Adult stem cells were successful in entering numerous clinical trials over the past 15 years in attempts to regenerate the heart.
Broughton, Kathleen M., Sussman, Mark A.
openaire   +3 more sources

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

Neuronal deletion of GSK3beta increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2 [PDF]

, 2014
BackgroundIn the adult central nervous system, axonal regeneration is abortive. Regulators of microtubule dynamics have emerged as attractive targets to promote axonal growth following injury as microtubule organization is pivotal for growth cone ...
Sílvia Vieira, Wittmann, Torsten, Sousa, Mónica M., Márcia A Liz, Pimentel, Helena I., Vera F Sousa, Telma E Santos, Vieira, Sílvia, Marques, Ana M., Sutherland, Calum; id_orcid, Hayley Pemble, Liz, Márcia A., Calum Sutherland, Mar, Fernando M., Mónica M Sousa, Pemble, Hayley, Sousa, Vera F., Helena I Pimentel, James R Woodgett, Morgado, Marlene M., Torsten Wittmann, Woodgett, James R., Santos, Telma E., Fernando M Mar, Ana M Marques, Marlene M Morgado   +25 more
core   +1 more source

Neuroinflammation as Fuel for Axonal Regeneration in the Injured Vertebrate Central Nervous System

Mediators of Inflammation, 2017
Damage to the central nervous system (CNS) is one of the leading causes of morbidity and mortality in elderly, as repair after lesions or neurodegenerative disease usually fails because of the limited capacity of CNS regeneration.
Ilse Bollaerts, Jessie Van houcke, Lien Andries, Lies De Groef, Lieve Moons   +4 more
doaj   +1 more source

Multilineage Potential and Self-Renewal Define an Epithelial Progenitor Cell Population in the Adult Thymus

Cell Reports, 2014
Thymic epithelial cells (TECs) are critical for T cell development and self-tolerance but are gradually lost with age. The existence of thymic epithelial progenitors (TEPCs) in the postnatal thymus has been inferred, but their identity has remained ...
Kahlia Wong, Natalie L. Lister, Marco Barsanti, Joanna M.C. Lim, Maree V. Hammett, Danika M. Khong, Christopher Siatskas, Daniel H.D. Gray, Richard L. Boyd, Ann P. Chidgey   +9 more
doaj   +1 more source

Review Article: Is Wnt Signaling an Attractive Target for the Treatment of Osteoarthritis?

Rheumatology and Therapy, 2020
Osteoarthritis is the most common chronic joint disease affecting millions of people worldwide and a leading cause of pain and disability. Increasing incidence of obesity and aging of the population are two factors that suggest that the impact of ...
Rik J. Lories, Silvia Monteagudo
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

The chimerical and multifaceted marine acoel Symsagittifera roscoffensis: from photosymbiosis to brain regeneration [PDF]

, 2014
International audienceA remarkable example of biological engineering is the capability of some marine animals to take advantage of photosynthesis by hosting symbiotic algae.
Probert, Ian, Pfannkuchen, A, Kurth, T, Hartenstein, Volker, Kurth, Thomas, Hartenstein, V, Volker eHartenstein, Reichert, H, Serge eVinogradov, Gaëlle Correc, Christophe eLechauve, Le Correc, G, Sam Dupont, Laguerre, Laurent, Anja Pfannkuchen, Laurent eLaguerre, Marie-José eGaret-Delmas, Entzeroth, R, Ian Probert, Marie-José Garet-Delmas, Vinogradov, S, Laurent Laguerre, Sam eDupont, Xavier Bailly, Heinrich Reichert, Reichert, Heinrich, Christophe Lechauve, Probert, I, Lechauve, Christophe, Serge Vinogradov, Rolf Entzeroth, Entzeroth, Rolf, Gaëlle eCorrec, Xavier eBailly, Rudolf eEntzeroth, Correc, Gaëlle, Volker Hartenstein, Pfannkuchen, Anja, Bailly, Xavier, Vinogradov, Serge, Laguerre, L, Garet-Delmas, Marie-José, Dupont, Sam, Anja ePfannkuchen, Bailly, X, Lechauve, C, Dupont, Samuel,, Thomas eKurth, Heinrich eReichert, Garet-Delmas, MJ, Ian eProbert, Thomas Kurth   +51 more
core   +1 more source

Ddx61-enriched condensates refine heart regeneration programs

Nature Communications
Gene regulatory mechanisms that underlie tissue regeneration have been largely studied at the level of transcription. Here, proximity labeling methods identify increased presence of the RNA helicase and P-body marker Ddx61 in adult zebrafish ...
Mira I. Pronobis, Sophia DeLuca, Siyun Lee, Lucas Garcia, Jianhong Ou, Nenad Bursac, Kenneth D. Poss   +6 more
doaj   +1 more source

Flow Cytometry Characterization and Analysis of Glial and Immune Cells from the Spinal Cord

Neuroglia
Several protocols have been developed with the aim of characterizing glial and immune cells from the central and peripheral nervous systems. However, a small number of these protocols have demonstrated the ability to yield satisfactory results following ...
Lilian de Oliveira Coser, Manuela Tosi Comelis, Débora Elisa da Costa Matoso, Luciana Politti Cartarozzi, Alexandre Leite Rodrigues de Oliveira   +4 more
doaj   +1 more source