FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source
Beyond Species Diversity: Functional Approaches Reveal Consistent Fauna Community Responses to Exotic Grass Invasion in Arid Lands. [PDF]
Ecol EvolRyan-Colton E +4 more
europepmc +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
León : órgano oficial de la Asociación Centro Región Leonesa.: León : órgano oficial de la Asociación Centro Región Leonesa - Año XI Número 86 - 1929 septiembre (01/09/1929) [PDF]
, 1929 Asociación Centro Región Leonesa (Buenos Aires)
core +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Histological architecture of the intersphincteric region of the anal canal: implications for the anatomical basis of anal fistula pathways. [PDF]
Int J Colorectal DisMuro S, Nakajima Y, Nimura A, Akita K.
europepmc +1 more source
León : órgano oficial de la Asociación Centro Región Leonesa.: León : órgano oficial de la Asociación Centro Región Leonesa - Año XVI Número 137 - 1935 marzo (01/03/1935) [PDF]
, 1935 Asociación Centro Región Leonesa (Buenos Aires)
core +1 more source
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source