Results 51 to 60 of about 167,063 (216)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Deep Learning Based on the Facial Color Images for Assisted Diagnosis of Chronic Renal Failure with Spleen–Kidney Qi Deficiency Syndrome

World Journal of Traditional Chinese Medicine
Objective: This study aimed to develop a machine learning model for the diagnosis of chronic renal failure (CRF) with spleen–kidney qi deficiency (SKQD) syndrome by investigating facial chromatic biomarkers based on traditional Chinese medicine (TCM ...
Luo Yang, Tong Tong, Yu Lu, Wei Wang, Chang-Yun Wei, Rui-Ting Wang, Yu-Lin Ouyang, Maryam Moossavi, Hong-Xia Liu, Xue-Ling Ma   +9 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Fascitis nodular en región facial en edades pediátricas Nodular fasciitis present in facial area in children

Revista Cubana de Estomatología, 2009
Propósito: Presentar 3 casos de fascitisnodular de región facial. Método: Se realizó un estudio de los pacientes que comprendió examen físico, análisis de laboratorio y radiológico. Se describió la conducta quirúrgica o médica realizada en cada caso y su
Dadonim Vila Morales, Ernesto Sánchez Cabrales   +1 more
doaj  

Nodular fasciitis of the oro-facial region

Contemporary Clinical Dentistry, 2012
Nodular fasciitis is a benign proliferative spindle-cell lesion that presents as a rapidly growing mass frequently being mistaken for a sarcoma. A rare presentation and treatment of nodular fasciitis in the cheek of an 8-year-old boy is described here ...
Priya Subramaniam, Ramdas Balakrishna, P Mahendra, K Gilhotra   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Decoding the baboon’s expressive capacity: facial microanatomy and the development of a PapioFACS

Scientific Reports
Facial mobility in primates reflects a dynamic interplay between anatomy and behavior, yet comparative data remain limited for many cercopithecines. Here, we present the first integrated anatomical and behavioral analysis of the facial mask in Papio ...
L. Rotenstreich, B. Geva, N. Edery, Y. Yehiel, S. Goder Cohen, L. Moss, S. EbenBari, Assaf Marom   +7 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Analysis of facial expression changes for the prediction of dialysis-related hypotension using facial monitoring: a fundamental study on prediction accuracy and feature extraction

Renal Replacement Therapy
Background Intradialytic hypotension (IDH) occurs in 20–40% of hemodialysis patients and is associated with adverse cardiovascular events and a poor prognosis.
Takehiro Okama, Kousuke Oiwa, Satoshi Suzuki, Yoshitaka Maeda, Akio Nozawa, Koji Sakuma, Akiko Uchida, Toshiharu Ishizuka, Sumihiko Sato   +8 more
doaj   +1 more source